Evidence map›Paper›PMID 30662835›Full record

ArticleInternational journal of ophthalmology2019

Metabolic profile analysis of free amino acids in experimental autoimmune uveoretinitis rat plasma.

Jun-Guo Guo, Xin-Miao Guo, Xing-Rong Wang, Jing-Zhen Tian, Hong-Sheng Bi

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Predictive Modeling for Metabolomics Data.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun-Guo GuoCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China.
Xin-Miao GuoSchool of Management, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China.
Xing-Rong WangShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Jinan 250002, Shandong Province, China.
Jing-Zhen TianCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China.
Hong-Sheng BiShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Jinan 250002, Shandong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the differences of amino acid (AA) levels in experimental autoimmune uveoretinitis (EAU).

methodsAA analysis of the plasma samples in EAU rats induced by interphotoreceptor retinoid-binding protein emulsion were performed with high performance liquid chromatography (HPLC) and phenylisothiocyanate (PITC) pre-column derivation methods were performed. Using partial least squares discriminant analysis (PLS-DA), the potential biomarkers were identified in EAU rat plasma, and the metabolic pathways related to EAU were further analyzed.

resultsThe method results showed that linear (

conclusionThe developed method is a simple, rapid and convenient for determination of AAs in EAU rat plasma, and these findings will provide a comprehensive insight on the metabolic profiling of the pathological changes in EAU.

Indexed as

amino acidexperimental autoimmune uveoretinitishigh performance liquid chromatographymetabolic profilephenylisothiocyanaterat

Identifiers

PMID30662835
PMCPMC6326922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.