Evidence map›Paper›PMID 30662824›Full record

ReviewNanotheranostics2019

Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment.

Derek Reichel, Manisha Tripathi, J Manuel Perez

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nanotheranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 166 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Phytochemical Profile and Biological Activities of the Roots ofBiochemistry research international · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Inhalable nanoparticle-based drug delivery system for non-small cell lung cancer therapy: promises and challenges.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
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  19. Review
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Derek ReichelDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Manisha TripathiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
J Manuel PerezDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Cedars-Sinai Medical Center · US

Funding

Polymeric nanoparticles with imaging capability for therapeutic peptide deliveryR01EB019288 · NIBIB · UNIVERSITY OF CENTRAL FLORIDA · PI KHALED, ANNETTE R, PEREZ, J MANUEL · 2014 to 2017
$1.2M
NIBIB NIH HHS R01 EB019288
6 · The paper itself

Abstract

Biological interactions between tumor-associated macrophages (TAMs), cancer cells and other cells within the tumor microenvironment contribute to tumorigenesis, tumor growth, metastasis and therapeutic resistance. TAMs can remodel the tumor microenvironment to reduce growth barriers such as the dense extracellular matrix and shift tumors towards an immunosuppressive microenvironment that protects cancer cells from targeted immune responses. Nanoparticles can interrupt these biological interactions within tumors by altering TAM phenotypes through a process called polarization. Macrophage polarization within tumors can shift TAMs from a growth-promoting phenotype towards a cancer cell-killing phenotype that predicts treatment efficacy. Because many types of nanoparticles have been shown to preferentially accumulate within macrophages following systemic administration, there is considerable interest in identifying nanoparticle effects on TAM polarization, evaluating nanoparticle-induced TAM polarization effects on cancer treatment using drug-loaded nanoparticles and identifying beneficial types of nanoparticles for effective cancer treatment. In this review, the macrophage polarization effects of nanoparticles will be described based on their primary chemical composition. Because of their strong macrophage-polarizing and antitumor effects compared to other types of nanoparticles, the effects of iron oxide nanoparticles on macrophages will be discussed in detail. By comparing the macrophage polarization effects of various nanoparticle treatments reported in the literature, this review aims to both elucidate nanoparticle material effects on macrophage polarization and to provide insight into engineering nanoparticles with more beneficial immunological responses for cancer treatment.

Indexed as

Cell PolarityMacrophagesNeoplasmsTumor MicroenvironmentAnimalsHumansNanoparticlesTumor EscapeCancerIron oxideMacrophage polarizationNanoparticlesTumor microenvironment

Identifiers

PMID30662824
PMCPMC6328304
OpenAlexW2905076856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.