Evidence map›Paper›PMID 30662782›Full record

ArticleCase reports in otolaryngology2018

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature.

Vivian Narana Ribeiro El-Achkar, Andressa Duarte, Fabiano Pinto Saggioro, Francisco Veríssimo De Mello Filho, Jorge Esquiche León, Alfredo Ribeiro-Silva, Estela Kaminagakura

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in otolaryngology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. tRNAJournal of clinical laboratory analysis · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vivian Narana Ribeiro El-AchkarDDS, PhD Student at Department of Bioscience and Oral Diagnosis, Science and Technology Institute, Universidade Estadual Paulista (UNESP), Sao Jose dos Campos, Brazil.ORCID 0000-0002-2800-552X
Andressa DuartePhD Student at Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
Fabiano Pinto SaggioroPhD, Assistant Physician at Pathology Service of Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
Francisco Veríssimo De Mello FilhoMD, PhD, Associated Professor at Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Jorge Esquiche LeónPhD, Professor at Department of Stomatology, Collective Health and Legal Dentistry, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
Alfredo Ribeiro-SilvaMD, PhD, Associated Professor at Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.ORCID 0000-0002-3579-5048
Estela KaminagakuraDDs, PhD, Associated Professor at the Department of Bioscience and Oral Diagnosis, Science and Technology Institute, Universidade Estadual Paulista (UNESP), Sao José dos Campos, Brazil.ORCID 0000-0003-2456-4516
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case. CASE REPORT: A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold. The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion. By using the chromogenic

resultsThe literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset. Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive. The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis.

conclusionsLP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP.

Identifiers

PMID30662782
PMCPMC6313995
OpenAlexW2903737714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.