Evidence map›Paper›PMID 30662655›Full record

ArticleAmerican journal of translational research2018

Effects of autophagy on the spermatogonia of chronic hypoxic mice.

Shaoming Zhu, Wei Li, Xiao Yang, Weimin Yu, Ting Rao, Yuan Ruan, Jinzhuo Ning, Run Yuan, Haoyong Li, Kun Jiang and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Shaoming ZhuDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Wei LiDepartment of Anesthesiology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Xiao YangDepartment of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University Wuhan 430060, China.
Weimin YuDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Ting RaoDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Yuan RuanDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Jinzhuo NingDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Run YuanDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Haoyong LiDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Kun JiangDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Chenglong LiDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Fan ChengDepartment of Urology, Renmin Hospital of Wuhan University Wuhan 430060, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicocele (VC) is a common cause of male infertility. An increasing number of studies have confirmed that chronic hypoxia plays an important role in male infertility caused by VC. Our previous study suggested that autophagy may have a crucial function in VC. Whether autophagy plays an important role in hypoxic spermatogonia remains unknown. We established a new method to study VC by culturing spermatogonia under hypoxic conditions to simulate the chronic hypoxic environment of VC. Moreover, the effects of autophagy on hypoxic spermatogonia were observed by regulating autophagy. Spermatogonia from GC-1 spg mice were cultured in vitro in chronic hypoxic conditions (2% O

Indexed as

autophagyGPX4Hif-1αhypoxiaLY294002spermatogoniavaricocele

Identifiers

PMID30662655
PMCPMC6325515
OpenAlexW2990804606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.