ArticleAmerican journal of translational research2018
Obesity attenuates force-induced tooth movement in mice with the elevation of leptin level: a preliminary translational study.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Cellular and Molecular Neuro-Bone Cell Interactions Drive Alveolar Bone Remodeling During Orthodontic Mechanical Loading.International journal of biological sciences · 2026Review
- Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure.International journal of oral science · 2024Article
- Impact of Leptin on the Expression Profile of Macrophages during Mechanical Strain In Vitro.International journal of molecular sciences · 2022Article
- Tooth movement, orofacial pain, and leptin, interleukin-1β, and tumor necrosis factor-α levels in obese adolescents.The Angle orthodontist · 2022Article
- Evaluation of Salivary Leptin Levels and Its Correlation with Class I, Class II, and Class III Facial Skeletal Pattern: A Prefatory Study.European journal of dentistry · 2021Article
- Hyperlipidemic Conditions Impact Force-Induced Inflammatory Response of Human Periodontal Ligament Fibroblasts Concomitantly Challenged withInternational journal of molecular sciences · 2021Article
- Distinguish fatty acids impact survival, differentiation and cellular function of periodontal ligament fibroblasts.Scientific reports · 2020Article
- Effects of the multifunctional hormone leptin on orthodontic tooth movement in rats.American journal of translational research · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing number of patients with high body-mass index (BMI) are encountered in the orthodontic clinic with the growing prevalence of obesity and overweight worldwide. Some clinical studies found that the rate of orthodontic tooth movement (OTM) in obese patients decreased. However, how obesity can impact OTM has not been determined yet. Here, we used the high-fat diet (HFD) induced obese mouse model to translate this clinical problem to the basic research, and back to exploring the potential clinical applications. C57BL/6J mice were fed with high-fat diet (HFD) for 5 weeks to induce obesity and orthodontic nickel-titanium springs were applied to the upper first molars to establish OTM model. The serum level of leptin was tested by ELISA. Mouse macrophage cell line RAW264.7 cells were used as osteoclast progenitor cells stimulated by sRANKL with the presence or absence of letpin
Indexed as
Identifiers
30662654PMC6325494W2991578362What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.