Evidence map›Paper›PMID 30662621›Full record

ArticleAmerican journal of translational research2018

Effects of sleeve gastrectomy on lipid and energy metabolism in ZDF rats via PI3K/AKT pathway.

Ying Feng, Chen Zhong, Jianxiang Niu, Lin Zhang, Yang Zhao, Wen Wang, Zelan Hu, Hui Wang, Ping He, Qinjie Ning and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ying FengLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Chen ZhongLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Jianxiang NiuThe Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050, Inner Mongolia, P. R. China.
Lin ZhangLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Yang ZhaoLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Wen WangLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Zelan HuLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Hui WangLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Ping HeLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Qinjie NingLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
JingJing XuLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
Jing ZhengLaboratory of Molecular Neuropharmacology, School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai 200237, P. R. China.
East China University of Science and Technology · CNInner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleeve Gastrectomy (SG), as the most effective bariatric surgery, has been using to chronically lose weight and control glucose metabolism in Type 2 diabetes mellitus patients. However, the underlining mechanism is still unclear. In this study, we performed SG on Zucker diabetes fatty (ZDF) rat and investigated visceral lipid metabolism and energy metabolism. After performance of SG, weight, food intake, fasting plasma glucose (FPG) and oral glucose tolerance teat (OGTT) of rats were measured. Furthermore, whole-body metabolic parameters were obtained through TSE LabMaster. Blood lipid and renal function were analyzed by serum from rats' tail vein. Furthermore, the renal genes expression was either detected by real-time PCR, while western blotting was employed to detect the AKT/PI3K proteins level in rats' kidney. Compared to control groups, body weight of ZDF rats treated with SG were significantly reduced, simultaneously with glucose homeostasis and energy metabolism improved including RER (

Indexed as

energy metabolismlipid metabolismPI3K/Akt pathwaySleeve gastrectomyZucker diabetes fatty rats

Identifiers

PMID30662621
PMCPMC6291694
OpenAlexW2999760698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.