Evidence map›Paper›PMID 30662538›Full record

ArticleJournal of Cancer2019

High expression of MiR-98 is a good prognostic factor in acute myeloid leukemia patients treated with chemotherapy alone.

Ning Hu, Zhiheng Cheng, Yifan Pang, Hongmian Zhao, Li Chen, Chao Wang, Tong Qin, Qianyu Li, Yu Han, Jinlong Shi and 1 more

Abstract read
In one paragraph

Article in Journal of Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  6. Review
  7. Review
  8. MiRNA-142-3P and FUS can be Sponged by Long Noncoding RNAFrontiers in molecular biosciences · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ning HuDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Zhiheng ChengTranslational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Yifan PangDepartment of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing, 100191, China.
Hongmian ZhaoDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Li ChenDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Chao WangDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Tong QinDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Qianyu LiDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Yu HanDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Jinlong ShiTranslational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Lin FuDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been demonstrated that microRNA-98 (miR-98) is dysregulated in multiple types of solid tumors, but its expression and impact in acute myeloid leukemia (AML) is unclear. To explore the prognostic role of miR-98 in AML, 164 AML patients with the miR-98 expression data were extracted from The Cancer Genome Atlas (TCGA) database and enrolled in this study. First, patients were divided into chemotherapy-only (chemotherapy) group and allogeneic hematopoietic stem cell transplant (allo-HSCT) group. Each group was then divided in two groups by the median expression level of miR-98. In chemotherapy group, high miR-98 expression was associated with longer event-free survival (EFS,

Indexed as

Acute myeloid leukemiaAllogeneic hematopoietic stem cell transplantationChemotherapyMiR-98Prognosis

Identifiers

PMID30662538
PMCPMC6329859

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.