ArticleJournal of exercise science and fitness2018
Low ALT blood levels are associated with lower baseline fitness amongst participants of a cardiac rehabilitation program.
Article in Journal of exercise science and fitness, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Low ALT Is Associated with IBD and Disease Activity: Results from a Nationwide Study.Journal of clinical medicine · 2024Article
- Association of AST/ALT (De Ritis) ratio with sarcopenia in a Chinese population of community-dwelling elderly.Heliyon · 2023Article
- Do low levels of alanine aminotransferase, a baseline marker of sarcopenia and frailty, associate with worse clinical outcomes among hospitalized COVID-19 patients? A Retrospective Cohort Study.Journal of frailty, sarcopenia and falls · 2023Article
- Association of Low Alanine Aminotransferase Values with Extubation Failure in Adult Critically Ill Patients: A Retrospective Cohort Study.Journal of clinical medicine · 2021Article
- Low ALT Levels Associated with Poor Outcomes in 8700 Hospitalized Heart Failure Patients.Journal of clinical medicine · 2020Article
- Frailty and Sarcopenia Assessment upon HospitalAdmission to Internal Medicine Predicts Length ofHospital Stay and Re-Admission: A ProspectiveStudy of 980 Patients.Journal of clinical medicine · 2020Article
- Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice.Translational stroke research · 2020Article
- High Serum Aspartate Aminotransferase, Underweight, and Weight Loss in Older People: Results of the KITCHEN-4.Healthcare (Basel, Switzerland) · 2020Article
- Article
- High Concentration of Serum Aspartate Aminotransferase in Older Underweight People: Results of the Kanagawa Investigation of the Total Check-Up Data from the National Database-2 (KITCHEN-2).Journal of clinical medicine · 2019Article
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Authors and funding
6 authors.
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Abstract
BACKGROUND/
objectiveObjective assessment tools for patients' frailty are lacking. Such tools would have been highly valuable for assessment of candidates for cardiac rehabilitation programs. Low ALT (Alanine aminotransferase) values were recently shown to be a promising parameter for objective, quantitative frailly assessment.
methodsThis was a retrospective study of patients participating in a cardiac rehabilitation program.
resultsPatients with lower ALT activity levels at the initiation of rehabilitation program had lower estimated METs values (6.86 vs. 7.73; p < 0.001), shorter stress test duration (06:41 vs. 07:44 min; p < 0.001), higher resting heart rate (72 ± 13 vs. 70 ± 13 BPM; p = 0.01) and lower heart rate reserve (49 ± 24 vs. 54 ± 24; p < 0.001). Multivariate linear modeling demonstrated that ALT values were Independent determinants of baseline exercise capacity (expressed in METs).
conclusionLower ALT values, measured prior to the initiation of cardiac rehabilitation programs may indicate frailty of patients and be indicative for poor rehabilitation outcomes. Further, prospective studies should assess the potential correlation between ALT values and rehabilitation efficiency. We aimed to assess the potential correlation between the baseline ALT values and the baseline exercise capacity, as expressed in METs (Metabolic equivalent of tasks). 3806 patients were included in our study.
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