Evidence map›Paper›PMID 30662343›Full record

ArticleInternational journal of biological sciences2019

Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells.

Bing Zhu, Shanxin Li, Lei Yu, Wei Hu, Dandan Sheng, Jing Hou, Naping Zhao, Xiaojuan Hou, Yechen Wu, Zhipeng Han and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

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  12. Application of phototherapeutic-based nanoparticles in colorectal cancer.International journal of biological sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Bing ZhuDepartment of Pharmacy, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Shanxin LiDepartment of Pharmacy, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Lei YuDepartment of Information, Changzheng Hospital, The Second Military Medical University, Shanghai, China.
Wei HuDepartment of Pharmacy, The Second Hospital of Anhui Medical University, Hefei, China.
Dandan ShengTumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
Jing HouGCP Office, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Naping ZhaoDepartment of Pharmacy, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Xiaojuan HouTumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
Yechen WuTumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
Zhipeng HanTumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
Lixin WeiTumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
Li ZhangDepartment of Pharmacy, The Second Hospital of Anhui Medical University, Hefei, China.
Second Military Medical University · CNEastern Hepatobiliary Surgery Hospital · CNAnhui Medical University · CNSecond Hospital of Anhui Medical University · CNXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the antitumor effect of sinoporphyrin sodium mediated photodynamic therapy (DVDMS-PDT) against human colorectal cancer (CRC) and to investigate the role of autophagy in its effect. Shrunken cells, condensed nuclei and increased levels of cleaved caspase-3 and Bax were observed in DVDMS-PDT treated HCT116 cells, reminiscent of apoptosis. DVDMS-PDT showed better antitumor efficiency in HCT116 cells than Photofrin mediated photodynamic therapy (PF-PDT) both

Indexed as

ApoptosisBlotting, WesternChloroquineColorectal NeoplasmsFlow CytometryHCT116 CellsHumansIn Situ Nick-End LabelingMicroscopy, Electron, TransmissionPhotochemotherapyPorphyrinsChloroquinePorphyrinssinoporphyrin sodiumapoptosisautophagychloroquinecolorectal cancerphotodynamic therapysinoporphyin sodium

Identifiers

PMID30662343
PMCPMC6329935
OpenAlexW2905536148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.