Evidence map›Paper›PMID 30662337›Full record

ArticleInternational journal of medical sciences2019

Bilirubin Attenuates ER Stress-Mediated Inflammation, Escalates Apoptosis and Reduces Proliferation in the LS174T Colonic Epithelial Cell Line.

Rohit Gundamaraju, Ravichandra Vemuri, Wai Chin Chong, Andrew Cameron Bulmer, Rajaraman Eri

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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  7. Review
  8. Bilirubin as a metabolic hormone: the physiological relevance of low levels.American journal of physiology. Endocrinology and metabolism · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rohit GundamarajuSchool of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
Ravichandra VemuriSchool of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
Wai Chin ChongSchool of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
Andrew Cameron BulmerSchool of Medical Science and Menzies Health Institute Queensland, Griffith University, Gold Coast, Qld, Australia.
Rajaraman EriSchool of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
University of Tasmania · AUGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mildly elevated serum unconjugated bilirubin (UCB) concentrations are associated with protection against disease conditions underpinned by cellular and metabolic stress. To determine the potential therapeutic efficacy of UCB we tested it in an

Indexed as

AdenocarcinomaApoptosisBilirubinBiomarkersCaspase 3Cell Line, TumorCell ProliferationColonic NeoplasmsEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEpithelial CellsHumansInflammationTunicamycinBilirubinBiomarkersCaspase 3Endoplasmic Reticulum Chaperone BiPHSPA5 protein, humanTunicamycinapoptosiscell proliferationcolon cancerER stressinflammation

Identifiers

PMID30662337
PMCPMC6332492
OpenAlexW2908562685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.