ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2019
Development and validation of a new HPLC analytical method for the determination of diclofenac in tablets.
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Investigation of the drug release modifying property of Pentadesma butyracea gum in diclofenac sodium matrix tablets.PloS one · 2026Article
- Molecular Docking and ADMET Analysis Strategy-based Stability Indicating RP-HPLC-PDA Method Development and Validation of Toremifene.Current computer-aided drug design · 2025Article
- Article
- Development of an RP-HPLC Method for Quantifying Diclofenac Diethylamine, Methyl Salicylate, and Capsaicin in Pharmaceutical Formulation and Skin Samples.Molecules (Basel, Switzerland) · 2024Article
- Nanomaterials as catalysts for the sensitive and selective determination of diclofenac.ADMET & DMPK · 2024Review
- Green UPLC method for estimation of ciprofloxacin, diclofenac sodium, and ibuprofen with application to pharmacokinetic study of human samples.Scientific reports · 2023Article
- HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions ofMolecules (Basel, Switzerland) · 2023Article
- Article
- Optimization of polyphenol extraction from3 Biotech · 2022Article
- Simultaneous Estimation of Escitalopram and Clonazepam in Tablet Dosage Forms Using HPLC-DAD Method and Optimization of Chromatographic Conditions by Box-Behnken Design.Molecules (Basel, Switzerland) · 2022Article
- Preparation and Evaluation of Polyvinylpyrrolidone Electrospun Nanofiber Patches of Pioglitazone for the Treatment of Atopic Dermatitis.AAPS PharmSciTech · 2022Article
- A Validated RP-HPLC Method for Simultaneous Determination of Cefixime and Clavulanic Acid Powder in Pediatric Oral Suspension.International journal of analytical chemistry · 2022Article
- Health risk assessment of endocrine disruptor bisphenol A leaching from plastic bottles of milk and soft drinks.Environmental science and pollution research international · 2021Article
- Quantification and Classification of Diclofenac Sodium Content in Dispersed Commercially Available Tablets by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Highly sensitive and selective colorimetric detection of dual metal ions (HgRSC advances · 2021Article
- Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method.International journal of analytical chemistry · 2021Article
- First derivative ATR-FTIR spectroscopic method as a green tool for the quantitative determination of diclofenac sodium tablets.F1000Research · 2020Article
- Application of Thin-Layer Chromatography in Combination with Densitometry for the Determination of Diclofenac in Enteric Coated Tablets.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Preparation, characterization, and antibacterial activity of diclofenac-loaded chitosan nanoparticles.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
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Abstract
A new selective and sensitive high-performance liquid chromatography (HPLC) method was developed for the quantification of diclofenac sodium (DS) in pharmaceutical dosage form using lidocaine as internal standard (IS). Chromatographic separation was achieved on a symmetry C18 column (4.6 mm × 150 mm, 3 μm spherical particles) using 0.05 M orthophosporic (pH 2.0) 35% and acetonitrile as 65%, as the mobile phase at a flow rate of 2.0 mL/min and monitored at 210 nm. The run time was 2 min. The method was validated to fulfill International Conference on Harmonisation (ICH) requirements and this validation included specificity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision and robustness. The calibration curve was linear over the concentration range from 10 to 200 µg/ml, and lower limit of detection of 12.5 ng/ml. The accuracy and precision of the method were within the acceptable limit of ±20% at the lower limit of quantitation and ±15% at other concentrations. Diclofenac was unstable at room temperature it showed more than 25% loss after 24 h. While, DS is very stable at refrigerator 4 °C auto-sampler, freeze/thaw cycles and 30 days storage in a freezer at -35 ± 2 °C. All results were acceptable and this confirmed that the method is suitable for its intended use in routine quality control and assay of drugs.
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