ArticleAnesthesia, essays and researches
Intravenous Low Dose Fentanyl versus Lignocaine in Attenuating the Hemodynamic Responses during Endotracheal Intubation: A Randomized Double-Blind Study.
Article in Anesthesia, essays and researches. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Effects of perioperative intravenous lidocaine on postoperative recovery quality in thoracoscopic surgery: a systematic review and meta-analysis.BMC anesthesiology · 2026Pooled it
- Prediction models for post-induction hypotension in patients undergoing general anesthesia: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Low-dose lidocaine attenuates fentanyl-induced cough: A double-blind randomized controlled trial.European journal of clinical pharmacology · 2022Trial
- Effects of intravenous lignocaine on haemodynamic responses to laryngoscopy and tracheal intubation in adults under general anaesthesia: A systematic review and meta-analysis.Indian journal of anaesthesia · 2025Article
- Effect of age on the median effective dose and 95% effective dose of intravenous fentanyl for blunting the hemodynamic response to tracheal intubation: A double-blind, up-and-down sequential method trial.Journal of anaesthesiology, clinical pharmacologyArticle
- Comparison of hemodynamic responses to nasal intubation in cancer patients receiving opioid-free general anesthesia versus standard regimen.Journal of anaesthesiology, clinical pharmacologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe laryngotracheal stimulation is known to cause reflex sympathoadrenal response with a marked increase in heart rate and blood pressure. Arrhythmias can be precipitated. The harmful nature of this response has been noted in patients at risk. Therefore, it is important to find an effective means of attenuating sympathetic response to laryngoscopy and intubation. The present study is undertaken to determine the efficacy of intravenous low dose fentanyl (2 μg/kg) and lignocaine (1.5 mg/kg) in attenuating hemodynamic response to laryngoscopy and tracheal intubation.
aimThe aim of this study is to compare the efficacy of intravenous low dose fentanyl (2 μg/kg) versus lignocaine (1.5 mg/kg) in attenuating the hemodynamic responses during endotracheal intubation. SETTINGS AND
designThis was double-blinded randomized controlled study. MATERIALS AND
methodsAfter obtaining institutional ethical clearance and informed consent, a total of 90 patients, with the American Society of Anaesthesiologists Physical Status I and II scheduled for elective surgeries, were selected randomly and divided into three groups of 30 each. The general anesthesia technique was standardized for all three groups as follows: Group 1 (control-received normal saline), Group 2 (Lignocaine 1.5 mg/kg), and Group 3 (Fentanyl 2 μg/kg). Heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure were recorded preinduction, postinduction and 1,3,5,7, and 10 min after endotracheal intubation. STATISTICAL ANALYSIS: Descriptive data presented as mean ± standard deviation and in percentage. Multiple group comparisons were made using one-way ANOVA followed by unpaired "
resultsThe fentanyl group showed significantly lesser rise (26%) in heart rate compared to lignocaine (33%) (
conclusionLignocaine and fentanyl both attenuated the rise in heart rate, though fentanyl was better. Lignocaine attenuated the rise in blood pressure with intubation whereas fentanyl prevented it totally. Of the two drugs low dose fentanyl 2 μg/kg i. v. bolus provides a consistent, reliable, and effective attenuation as compared to lignocaine 1.5 mg/kg i. v. bolus.
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