ArticleJournal of Ayurveda and integrative medicine
Protective role of hydroalcoholic extract of Cajanus cajan Linn leaves against memory impairment in sleep deprived experimental rats.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 17 citations in OpenAlex.
- The Effects of Antioxidant Approved Drugs and Under Investigation Compounds with Potential of Improving Sleep Disorders and their Associated Comorbidities Associated with Oxidative Stress and Inflammation.Mini reviews in medicinal chemistry · 2025Review
- Sleep Deprivation-Induced Oxidative Stress in Rat Models: A Scoping Systematic Review.Antioxidants (Basel, Switzerland) · 2023Article
- Potential Therapeutic Benefits of Honey in Neurological Disorders: The Role of Polyphenols.Molecules (Basel, Switzerland) · 2022Review
- BACE1 and cholinesterase inhibitory activities of compounds fromIn silico pharmacology · 2021Article
- The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundThe plant Cajanus cajan had earlier shown protective effect against hypoxic-ischemic brain damage in rats.
objectiveHence, hydroalcoholic extract of C. cajan Linn leaves (HECC) was evaluated for its protective role against memory impairment in sleep-deprived Sprague Dawley rats. MATERIALS AND
methodsAdult rats were divided into five groups each consisting of 5 rats (n = 5). Groups I, II, III, IV and V received 1 mL/kg 1% CMC, 1 mL/kg 1% CMC, 200 mg/kg HECC, 400 mg/kg HECC and 200 mg/kg piracetam respectively as per b.wt. orally everyday for 14 days. Animals of every groups except group-I were subjected to sleep-deprivation from 15th to 19th day for induction of memory impairment. Behavioral activities i.e., elevated plus maze test and locomotor activity were evaluated. Afterwards, brain was isolated from the sacrificed animals for biochemical investigation of acetylcholinesterase (AChE); antioxidant activities i.e., catalase (CAT), superoxide dismutase (SOD), lipid peroxide; and histopathological changes.
resultsThe percent number of entries, number of entries in open arm, AChE activity, lipid peroxide activity of HECC-treated group-III and group-IV were significantly (p < 0.01) decreased while, their CAT and SOD activities were significantly (p < 0.01) increased in dose-dependent manner as compared to sleep-deprived group-II. The activities of group-IV were almost significantly equivalent to that of piracetam-treated group-V. Protective effect of HECC was well supported with brain's histopathology.
conclusionHECC possesses a protective effect against memory impairment indicating its therapeutic efficacy against memory loss as in Alzheimer's disease. Probable underlying mechanisms may be brain's AChE inhibition and increased antioxidant potential by HECC.
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