ArticleJournal of the American Heart Association2019
Changing Epidemiology of Hypoplastic Left Heart Syndrome: Results of a National Swedish Cohort Study.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ethical considerations and multidisciplinary care for pediatric patients with hypoplastic left heart syndrome: a narrative review with a systematic search.Frontiers in cardiovascular medicine · 2025Pooled it
- Timing of Balloon Atrial Septostomy in Hybrid Stage 1 Palliation in Hypoplastic Left Heart Syndrome.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- A phenotyping algorithm for classification of single ventricle physiology using electronic health records.JAMIA open · 2025Article
- Antenatal spectrum of congenital heart disease: Experience from a Northern Indian referral unit.Bioinformation · 2025Article
- Long-Term Survival After Single-Ventricle Palliation: A Swedish Nationwide Cohort Study.Journal of the American Heart Association · 2024Article
- Long-term survival in patients with univentricular heart: A nationwide, register-based cohort study.International journal of cardiology. Congenital heart disease · 2024Article
- Hybrid stage 1 palliation for HLHS: the experience of a tertiary center in a developing country.Frontiers in cardiovascular medicine · 2024Article
- Hypoplastic Left Heart Syndrome: Signaling & Molecular Perspectives, and the Road Ahead.International journal of molecular sciences · 2023Review
- Hypoplastic Left Heart Syndrome: A Case Report.JNMA; journal of the Nepal Medical Association · 2023Article
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- The Alberta Congenital Anomalies Surveillance System: a 40-year review with prevalence and trends for selected congenital anomalies, 1997-2019.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2023Article
- Prenatal diagnosis of congenital heart defects: echocardiography.Translational pediatrics · 2021Review
- Role of gated cardiac computed tomographic angiography in the evaluation of postsurgical complications after stage I Norwood procedure and its implications on management: a comparative study with two-dimensional echocardiography.Pediatric radiology · 2021Article
- Survival in Children With Congenital Heart Disease: Have We Reached a Peak at 97%?Journal of the American Heart Association · 2020Article
- Reports of 2 Rare Associations of Hypoplastic Left Heart Syndrome.JACC. Case reports · 2019Article
- Changing Epidemiology of Hypoplastic Left Heart Syndrome: Results of a National Swedish Cohort Study.Journal of the American Heart Association · 2019Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Norwood surgery provides a palliative surgical option for hypoplastic left heart syndrome and has been available in Sweden since 1993. The practice of prenatal ultrasound screening was gradually implemented in the same era, resulting in an increased prenatal detection rate. Our primary aims were to study changes in the incidence of live births, prenatal detection rate, and the termination of pregnancies over time. The secondary aims were to study the proportion of live-borns undergoing surgery and to identify factors that influenced whether surgery was or was not performed. Methods and Results Neonates with hypoplastic left heart syndrome with aortic atresia born 1990-2010 were identified through national databases, surgical files, and medical records. The fetal incidence was estimated from the period when prenatal screening was rudimentary. The study period was divided into the presurgical, early surgical, and late surgical periods. The incidence was calculated as the overall yearly incidence for each time period and sex separately. Factors influencing whether surgery was performed were analyzed using Cox-logistic regression. The incidence at live birth decreased from 15.4 to 8.4 per 100 000. The prenatal detection rate increased from 27% to 63%, and terminations increased from 19% to 56%. The odds of having surgery was higher in the late period and higher in the group with prenatal diagnosis. Conclusions We observed a decrease in incidence of live-borns with hypoplastic left heart syndrome aortic atresia. There was in increase in prenatal detection rate and an increase in termination of pregnancy. The proportion of live-borns who underwent surgery increased between time periods.
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