Evidence map›Paper›PMID 30661346›Full record

ArticleJournal of microbiology and biotechnology2018

Co-Expression of a Chimeric Protease Inhibitor Secreted by a Tumor-Targeted

David Quintero, Jamie Carrafa, Lena Vincent, Hee Jong Lee, James Wohlschlegel, David Bermudes

Open access · greenAbstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Tryptophanase Expressed byMicroorganisms · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David QuinteroDepartment of Biology, California State University Northridge, Northridge, CA 91330-8303, USA.
Jamie CarrafaDepartment of Biology, California State University Northridge, Northridge, CA 91330-8303, USA.
Lena VincentDepartment of Biology, California State University Northridge, Northridge, CA 91330-8303, USA.
Hee Jong LeeDepartment of Biological Chemistry, David Geffen School of Medicine at the University of California at Los Angeles, 615 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
James WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine at the University of California at Los Angeles, 615 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
David BermudesDepartment of Biology, California State University Northridge, Northridge, CA 91330-8303, USA.
California State University, Northridge · US

Funding

RISE@CSUN: Preparing Students for Careers in Basic Biomedical SciencesR25GM063787 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI ZAVALA, MARIAELENA B · 2001 to 2018
$9.2M
TUMOR-TARGETING SALMONELLA EXPRESSING TUMOR-SELECTIVE CYTOTOXIC PROTEINS IN COMBINATION WITH PROTEASE INHIBITORSSC3GM098207 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI BERMUDES, DAVID G · 2013 to 2022
$870k
NIGMS NIH HHS R25 GM063787NIGMS NIH HHS SC3 GM098207
6 · The paper itself

Abstract

Sunflower trypsin inhibitor (SFTI) is a 14-amino-acid bicyclic peptide that contains a single internal disulfide bond. We initially constructed chimeras of SFTI with N-terminal secretion signals from the

Indexed as

ChimeraProteolysisADP Ribose TransferasesAmino Acid SequenceBacterial Outer Membrane ProteinsBacterial ToxinsBiological TransportBreast NeoplasmsCell Line, TumorDisulfidesEnzyme InhibitorsEscherichia coliEscherichia coli ProteinsExotoxinsFemaleHumansADP Ribose TransferasesBacterial Outer Membrane ProteinsBacterial ToxinsDisulfidesEnzyme InhibitorsEscherichia coli ProteinsExotoxinsOMPA outer membrane proteinsPeptides, CyclicProtease InhibitorsProtective AgentsPseudomonas aeruginosa Exotoxin ARecombinant Fusion ProteinsSFTI-1 peptide, sunflowerTrypsinVirulence FactorsYebF protein, E coliOTG-PE38KProtease inhibitorssunflower trypsin inhibitor (SFTI)tumor-targeted SalmonellaVNP20009YebF

Identifiers

PMID30661346
PMCPMC6883771
OpenAlexW2942684314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.