ArticleJournal of exercise nutrition & biochemistry2018
Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults.
Article in Journal of exercise nutrition & biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Association between grip strength and non-alcoholic fatty liver disease: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Association between Non-Alcoholic Fatty Liver Disease and Mediterranean Lifestyle: A Systematic Review.Nutrients · 2021Pooled it
- Possible association between metabolic dysfunction-associated steatotic liver disease predictors and hand grip strength.Scientific reports · 2025Article
- Association of relative hand grip strength with myocardial infarction and angina pectoris in the Korean population: a large-scale cross-sectional study.BMC public health · 2024Article
- Low Muscle Strength as Risk Factor for Non-Alcoholic Fatty Liver Disease in Different Metabolic Conditions.Korean journal of family medicine · 2024Article
- Associations of Fatty Liver Disease With Recovery After Traumatic Injury.The Journal of surgical research · 2023Article
- Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers.Metabolites · 2022Article
- Relationships between Socioeconomic Status, Handgrip Strength, and Non-Alcoholic Fatty Liver Disease in Middle-Aged Adults.International journal of environmental research and public health · 2021Article
- Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients.Scientific reports · 2021Article
- Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study.Frontiers in medicine · 2021Article
- Association of grip strength with non-alcoholic fatty liver disease: investigation of the roles of insulin resistance and inflammation as mediators.European journal of clinical nutrition · 2020Article
- Significant Correlation Between Grip Strength and m2bpgi in Patients with Chronic Liver Diseases.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study examined the association of hand-grip strength (HGS) and non-alcoholic fatty liver disease (NAFLD) index in older adults.
methodsThis was a cross-sectional study involving 538 older adults with mean age of 74.3±6.4 years. Body composition parameters including height, percent body fat, body mass index (BMI), waist circumference (WC), was determined using body composition analyzer. HGS was assessed using a dynamometer, and NAFLD was diagnosed by the simple NAFLD score (SNS), hepatic steatosis index (HSI), NAFLD fibrosis score (NFS), and fibrosis 4 calculator (FIB-4). Based on relative HGS, subjects were classified as High HGS, Mid HGS, and Low HGS group. Based on SNS, HSI, NFS and FIB-4 score, subjects were classified as High risk and Low risk group. Logistic regression analyses were used to determine the odds ratio (OR) and 95% confidence interval (CI) of HGS levels for having steatosis and fibrosis.
resultsThere were linear decreases in NAFLD index such as SNS (P<.001), HSI (P<.001), NFS (P=.001), and FIB-4 (P=.041) across incremental HGS levels. Compared to the High HGS group (reference), the Low HGS group had significantly higher ORs of having SNS (OR=4.583, 95% CI=2.608-8.054, P<.001), HSI (OR=11.697, 95% CI=5.261-26.005, P<.001), and NFS (OR=1.709, 95% CI=1.005-2.907, P=.048).
conclusionThe current findings suggest that a lifestyle intervention consisting of a normal weight and physical fitness should be promoted as a preventive means against NAFLD associated with HGS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.