Evidence map›Paper›PMID 30661072›Full record

ArticleNeuroepidemiology2019

Cancers Preceding Parkinson's Disease after Adjustment for Bias in a Danish Population-Based Case-Control Study.

Xin Cui, Zeyan Liew, Johnni Hansen, Pei-Chen Lee, Onyebuchi A Arah, Beate Ritz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroepidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.Movement disorders : official journal of the Movement Disorder Society · 2023
    Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
  8. Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024
    Review
  9. Article
  10. Epidemiology of Parkinson's Disease: An Update.Current neurology and neuroscience reports · 2024
    Review
  11. Review
  12. Article
  13. Observational
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Xin CuiDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California, USA.
Zeyan LiewDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California, USA.
Johnni HansenDanish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
Pei-Chen LeeDepartment of Health Care Management, College of Healthcare Administration and Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Onyebuchi A ArahDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California, USA.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California, USA, britz@ucla.edu.
University of California, Los Angeles · USDanish Cancer Society · DKNational Taipei University of Nursing and Health Science · TW

Funding

PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Registry Study of Parkinsons Disease in DenmarkR01ES013717 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2006 to 2010
$4.5M
Air Pollution and Adverse Birth OutcomesR01ES010960 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R · 2001 to 2004
$921k
Air Pollution and Parkinson's in the Danish PASIDA StudyR21ES022391 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2013 to 2014
$380k
Neurodevelopmental effects of Perfluorinated ChemicalsK99ES026729 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIEW, ZEYAN · 2017 to 2018
$317k
NIEHS NIH HHS K99 ES026729NIEHS NIH HHS R01 ES010544NIEHS NIH HHS R01 ES010960NIEHS NIH HHS R01 ES013717NIEHS NIH HHS R21 ES022391
6 · The paper itself

Abstract

Cancer patients are at lower risk of developing Parkinson's disease (PD) compared with the general population. One explanation is the negative association between smoking and PD, but PD risk is also lower for cancers not related to smoking. Another explanation is survival bias where death from cancer may act as a competing risk. We conducted a large population-based case-control study in Denmark and investigated whether cancer diagnosis reduced the risk of developing PD even after adjusting for important risk factors including smoking, physical activity, and lifetime oestrogen status. Using probabilistic bias analysis we quantified the influence of survival bias. We estimated negative point estimates (ORs) between cancers and PD for all cancers except skin, female breast, and ill-defined and unspecified 0.85 (95% CI 0.59-1.21); smoking-related cancers 0.75 (95% CI 0.45-1.23); and cancers not related to smoking 0.82 (95% CI 0.49-1.38) that are very similar to those previously reported for a much larger Danish register only based study, even though our confidence intervals include the null. These effect estimates shifted towards the null after accounting for survival bias but most bias-adjusted ORs remained below 1 within the range of priors considered in simulations. Overall, cancer patients have a lower risk of developing PD even after controlling for cancer-related lifestyles factors and correcting for survival bias.

Indexed as

Life StylePopulation SurveillanceAdultAgedBiasCase-Control StudiesDenmarkFemaleHumansMaleMiddle AgedNeoplasmsParkinson DiseaseRegistriesRisk FactorsBias analysisCancerParkinson’s diseaseSurvival

Identifiers

PMID30661072
PMCPMC6482096
OpenAlexW2910766075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.