ArticleChest2019
Use of CT Imaging to Quantify Progression and Response to Treatment in Lymphangioleiomyomatosis.
Article in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Guideline
- Novel Pulmonary Cyst Characteristics Associated with the Diffusing Capacity of the Lung in Lymphangioleiomyomatosis: A Cross-Sectional Clinical Trial.Annals of the American Thoracic Society · 2023Trial
- Diffuse cystic lung diseases-a primer for radiologists.BJR open · 2026Review
- Review
- Ultra-low dose chest CT with silver filter and deep learning reconstruction significantly reduces radiation dose and retains quantitative information in the investigation and monitoring of lymphangioleiomyomatosis (LAM).European radiology · 2024Article
- Quantification of Proteus syndrome-associated lung disease.Orphanet journal of rare diseases · 2024Article
- Automated Segmentation and Measurements of Pulmonary Cysts in Lymphangioleiomyomatosis across Multiple CT Scanner Platforms over a Period of Two Decades.Bioengineering (Basel, Switzerland) · 2023Article
- Sporadic Lymphangioleiomyomatosis Disease: A Case Report.Iranian journal of medical sciences · 2023Article
- Computer grading of lung disease severity in patients with lymphangioleiomyomatosis referred for transplantation.BMC pulmonary medicine · 2022Article
- Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis.The European respiratory journal · 2022Article
- Mechanobiology of Pulmonary Diseases: A Review of Engineering Tools to Understand Lung Mechanotransduction.Journal of biomechanical engineering · 2021Review
- Ultra-Small Lung Cysts Impair Diffusion Without Obstructing Air Flow in Lymphangioleiomyomatosis.Chest · 2021Article
- Pregnancy in lymphangioleiomyomatosis: clinical and lung function outcomes in two national cohorts.Thorax · 2020Article
- Quantitative analysis of airway obstruction in lymphangioleiomyomatosis.The European respiratory journal · 2020Article
- Clinical value of texture analysis in differentiation of urothelial carcinoma based on multiphase computed tomography images.Medicine · 2020Observational
- Clinical CT underestimation of the percentage volume occupied by cysts in patients with lymphangioleiomyomatosis.Clinical imaging · 2020Article
- CT grading of lung disease in lymphangioleiomyomatosis.AJR. American journal of roentgenology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn lymphangioleiomyomatosis (LAM), infiltration of the lungs with smooth muscle-like LAM cells results in cystic destruction and decline in lung function, effects stabilized by sirolimus therapy. LAM lung disease is followed, in part, by high-resolution CT scans. To obtain further information from these scans, we quantified changes in lung parenchyma by analyzing image "texture."
methodsTwenty-six texture properties were quantified by analyzing the distribution and intensity of pixels with a computer-aided system. Both cross-sectional and longitudinal studies were performed to examine the relationships between texture properties, cyst score (percentage of lung occupied by cysts), FEV
resultsIn the cross-sectional study, 18 texture properties showed significant positive correlations with cyst score. Cyst score and 13 of the 18 texture properties showed significant differences in rates of change after sirolimus treatment; 11 also significantly predicted FEV
conclusionsIncreased cyst score was associated with increased texture degradation near cysts. Sirolimus treatment improved lung texture surrounding cysts and stabilized cyst score. Eleven texture properties were associated with FEV
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.