Evidence map›Paper›PMID 30660732›Full record

ReviewGastroenterology2019

Epidemiology, Pathophysiology, and Treatment of Diverticulitis.

Lisa L Strate, Arden M Morris

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 21 pooled it
41.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 21 syntheses or guidelines pooled it, 435 citations in OpenAlex.

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  6. Guideline
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  14. Antibiotics for uncomplicated diverticulitis.The Cochrane database of systematic reviews · 2022
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  17. Guideline
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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lisa L StrateDivision of Gastroenterology, University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington. Electronic address: lstrate@uw.edu.
Arden M MorrisS-SPIRE Center and Department of Surgery, Stanford University, Stanford, California.
Harborview Medical Center · USStanford University · US

Funding

Inflammation and Risk of DiverticulitisR01DK101495 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STRATE, LISA L · 2014 to 2022
$4.4M
NIDDK NIH HHS R01 DK101495
6 · The paper itself

Abstract

Diverticulitis is a prevalent gastrointestinal disorder that is associated with significant morbidity and health care costs. Approximately 20% of patients with incident diverticulitis have at least 1 recurrence. Complications of diverticulitis, such as abdominal sepsis, are less likely to occur with subsequent events. Several risk factors, many of which are modifiable, have been identified including obesity, diet, and physical inactivity. Diet and lifestyle factors could affect risk of diverticulitis through their effects on the intestinal microbiome and inflammation. Preliminary studies have found that the composition and function of the gut microbiome differ between individuals with vs without diverticulitis. Genetic factors, as well as alterations in colonic neuromusculature, can also contribute to the development of diverticulitis. Less-aggressive and more-nuanced treatment strategies have been developed. Two multicenter, randomized trials of patients with uncomplicated diverticulitis found that antibiotics did not speed recovery or prevent subsequent complications. Elective surgical resection is no longer recommended solely based on number of recurrent events or young patient age and might not be necessary for some patients with diverticulitis complicated by abscess. Randomized trials of hemodynamically stable patients who require urgent surgery for acute, complicated diverticulitis that has not improved with antibiotics provide evidence to support primary anastomosis vs sigmoid colectomy with end colostomy. Despite these advances, more research is needed to increase our understanding of the pathogenesis of diverticulitis and to clarify treatment algorithms.

Indexed as

Diverticulitis, ColonicHumansRisk FactorsTreatment OutcomeChronic ManifestationsFunctional SymptomsImmunosuppressionLaparoscopic LavageSmoldering Diverticulitis

Identifiers

PMID30660732
PMCPMC6716971
OpenAlexW2909090819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.