Evidence map›Paper›PMID 30660574›Full record

Trial reportSchizophrenia research2019

Divergence of subjective and performance-based cognitive gains following cognitive training in schizophrenia.

Emily B H Treichler, Michael L Thomas, Andrew W Bismark, William C Hochberger, Melissa Tarasenko, John Nungaray, Lauren Cardoso, Yash B Joshi, Wen Zhang, Joyce Sprock and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emily B H TreichlerVA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, United States; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Michael L ThomasDepartment of Psychology, Colorado State University, Fort Collins, CO, United States; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Andrew W BismarkVA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, United States; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States.
William C HochbergerVA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, United States; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Melissa TarasenkoVA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, United States; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States.
John NungarayDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Lauren CardosoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Yash B JoshiDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Wen ZhangDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Joyce SprockDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Neal SwerdlowDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Amy N CohenVA Desert Pacific MIRECC, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States.
Gregory A LightVA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, United States; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States. Electronic address: glight@ucsd.edu.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
Neuroimaging and Neurocognitive Computerized Adaptive Testing in SchizophreniaK23MH102420 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMAS, MICHAEL L · 2014 to 2018
$815k
NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1 TR001442NIMH NIH HHS K23 MH102420
6 · The paper itself

Abstract

backgroundCognitive training is effective for improving cognitive performance among people with schizophrenia. An individual's perception of their own cognition is dissociable from performance on objective cognitive tests. Since subjective cognitive benefit may impact engagement, motivation, and satisfaction with time-intensive cognitive interventions, this study aimed to determine whether subjective cognitive difficulties improve in conjunction with cognitive gains following 30 h of cognitive training.

methodsPatients with schizophrenia or schizoaffective disorder (N = 46) were randomized to treatment as usual (TAU) or TAU augmented with auditory-targeted cognitive training (TCT). All participants completed assessment batteries at baseline and follow-up. As previously reported, the TCT group showed significant improvements in verbal learning and memory and reductions in auditory hallucinations relative to the TAU group.

resultsSubjective cognitive difficulties did not significantly improve following TCT, even among TCT participants who showed improvements in cognitive performance (all ps > 0.05). Subjective cognitive difficulties were significantly associated with severity of depressive symptoms and hallucinations (r = 0.48 and r = 0.28, p < 0.001), but not global or specific domains of cognition (all rs < 0.1) at baseline. There were no significant relationships between change in subjective cognitive difficulties and change in cognitive or clinical variables (all ps > 0.05). DISCUSSION: Patients with schizophrenia do not detect change in their cognition following cognitive training, even among those who showed robust gains in cognitive performance. Failure to detect improvement may undermine treatment engagement, motivation, and satisfaction. Translating score improvements on the cognitive exercises into tangible metrics, and providing ongoing, clinician-delivered feedback on performance may facilitate patient ability to detect improvements and improve motivation to engage with cognitive training interventions.

Indexed as

Cognitive RemediationPatient Reported Outcome MeasuresAdultCognitive DysfunctionFemaleHumansMaleMiddle AgedPsychotic DisordersSchizophreniaYoung AdultCognitive trainingPatient-reported outcomesSchizophreniaSubjective cognitive difficultiesSymptoms

Identifiers

PMID30660574
PMCPMC7032664

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.