Evidence map›Paper›PMID 30660541›Full record

ArticleJACC. Cardiovascular imaging2019

Acute Microvascular Impairment Post-Reperfused STEMI Is Reversible and Has Additional Clinical Predictive Value: A CMR OxAMI Study.

Alessandra Borlotti, Michael Jerosch-Herold, Dan Liu, Dafne Viliani, Alessia Bracco, Mohammad Alkhalil, Giovanni Luigi De Maria, OxAMI Study Investigators, Keith M Channon, Adrian P Banning and 4 more

Open access · hybridAbstract read
In one paragraph

Article in JACC. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  6. Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy.Apoptosis : an international journal on programmed cell death · 2025
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  15. PET/MR imaging of inflammation in atherosclerosis.Nature biomedical engineering · 2023
    Review
  16. Angiography-derived index of microvascular resistance in takotsubo syndrome.The international journal of cardiovascular imaging · 2023
    Article
  17. Article
  18. Article
  19. Coronary Microvascular Dysfunction.Journal of clinical medicine · 2020
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Alessandra BorlottiDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Michael Jerosch-HeroldDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Dan LiuDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Dafne VilianiDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Alessia BraccoDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Mohammad AlkhalilDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Giovanni Luigi De MariaDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
OxAMI Study Investigators
Keith M ChannonOxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom.
Adrian P BanningOxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom.
Robin P ChoudhuryDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Stefan NeubauerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Rajesh K KharbandaOxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom.
Erica Dall'ArmellinaDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. Electronic address: e.dallarmellina@leeds.ac.uk.
John Radcliffe Hospital · GBUniversity of Oxford · GBBrigham and Women's Hospital · US

Funding

British Heart Foundation FS/13/71/30378British Heart Foundation SP/17/16/33519Department of Health
6 · The paper itself

Abstract

objectivesThis study sought to investigate the clinical utility and the predictive relevance of absolute rest myocardial blood flow (MBF) by cardiac magnetic resonance (CMR) in acute myocardial infarction.

backgroundMicrovascular obstruction (MVO) remains one of the worst prognostic factors in patients with reperfused ST-segment elevation myocardial infarction (STEMI). Clinical trials have focused on cardioprotective strategies to maintain microvascular functionality, but there is a need for a noninvasive test to determine their efficacy.

methodsA total of 64 STEMI patients post-primary percutaneous coronary intervention underwent 3-T CMR scans acutely and at 6 months (6M). The protocol included cine function, T

resultsAcute MBF

conclusionsAcute MBF by CMR could represent a novel quantitative imaging biomarker of microvascular reversibility, and it could be used to identify patients who may benefit from more intensive or novel therapies.

Indexed as

Coronary CirculationMagnetic Resonance Imaging, CineMicrocirculationAgedContrast MediaFemaleHumansMaleMeglumineMiddle AgedMyocardial Perfusion ImagingOrganometallic CompoundsPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesRecovery of FunctionContrast Mediagadoterate meglumineMeglumineOrganometallic Compoundsacute myocardial infarctionmagnetic resonancemyocardial blood flow

Identifiers

PMID30660541
PMCPMC6718360
OpenAlexW2911028566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.