ArticleExperimental neurology2019
Aripiprazole and environmental enrichment independently improve functional outcome after cortical impact injury in adult male rats, but their combination does not yield additional benefits.
Abstract read
In one paragraph
Article in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Pre-operative environmental enrichment does not yield a prophylactic effect against traumatic brain injury-induced neurobehavioral deficits.Experimental neurology · 2025Article
- The role of the sensory input intervention in recovery of the motor function in hypoxic ischemic encephalopathy rat model.Journal of neurophysiology · 2024Article
- Cognitive and Motor Function Effects of Antipsychotics in Traumatic Brain Injury: A Systematic Review of Pre-Clinical Studies.Neurotrauma reports · 2024Article
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Enriching adult male rats prior to traumatic brain injury does not attenuate neurobehavioral or histological deficits.Brain research · 2023Article
- Antipsychotic Drugs: The Antithesis to Neurorehabilitation in Models of Pre-Clinical Traumatic Brain Injury.Neurotrauma reports · 2023Article
- Therapeutic Effects of Aripiprazole in the 5xFAD Alzheimer's Disease Mouse Model.International journal of molecular sciences · 2021Article
- Environmental enrichment and amantadine confer individual but nonadditive enhancements in motor and spatial learning after controlled cortical impact injury.Brain research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Sonya BesagarPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Hannah L RadabaughPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Isabel H BleimeisterPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Elizabeth A MeyerPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Peter J NiesmanPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Jeffrey P ChengPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Corina O BondiPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States; Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Anthony E KlinePhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, United States; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15213, United States; Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States; Psychology, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address: klineae@upmc.edu.
Funding
Optimizing Environmental Enrichment to Model Preclinical NeurorehabilitationR01NS084967 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2014 to 2025
$3.7MEnvironmental Enrichment and Cholinergic Mechanisms after TBIR01NS060005 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2009 to 2013
$1.6MUnderstanding the Impact of Antipsychotic Drugs on Recovery After TBIR01HD069620 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2012 to 2016
$1.6MEffects of Chronic Adolescent Stress on Cognitive and Emotional Behavior After Adult TBIR21NS099674 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2017 to 2018
$429kMultimodal Assessment of Behavioral flexibility after Frontal Brain TraumaR21NS099683 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONDI, CORINA OANA · 2016 to 2017
$426kSustained Attention and Executive Functioning After Brain TraumaR03NS094950 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONDI, CORINA OANA · 2016 to 2017
$154kNICHD NIH HHS R01 HD069620NINDS NIH HHS R01 NS060005NINDS NIH HHS R01 NS084967NINDS NIH HHS R03 NS094950NINDS NIH HHS R21 NS099674NINDS NIH HHS R21 NS099683
Abstract
Typical antipsychotic drugs (APDs) with D
Indexed as
EnvironmentAnimalsAntipsychotic AgentsAripiprazoleBrain Injuries, TraumaticCerebral CortexHousing, AnimalMaleMaze LearningMemoryPsychomotor PerformanceRatsRats, Sprague-DawleySpatial LearningTreatment OutcomeAntipsychotic AgentsAripiprazoleAntipsychotic drugsBehavioral outcomeControlled cortical impactFunctional recoveryLearning and memoryMorris water mazeTraumatic brain injury
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.