Evidence map›Paper›PMID 30659773›Full record

ArticlePhysiological reports2019

Age and sex differences in sympathetic and hemodynamic responses to hypoxia and cold pressor test.

Amanda J Miller, Jian Cui, J Carter Luck, Lawrence I Sinoway, Matthew D Muller

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
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  5. Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022
    Trial
  6. Review
  7. Article
  8. Cold-induced vasodilation: A meta-analysis.Temperature (Austin, Tex.) · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Influence of body dimensions and sex on cold-induced vasodilation.European journal of applied physiology · 2025
    Article
  15. Elevated blood pressure, stroke volume, and vascular tone in young women who use oral contraception.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amanda J MillerPenn State Heart and Vascular Institute, Penn State University College of Medicine, Hershey, Pennsylvania.
Jian CuiPenn State Heart and Vascular Institute, Penn State University College of Medicine, Hershey, Pennsylvania.
J Carter LuckPenn State Heart and Vascular Institute, Penn State University College of Medicine, Hershey, Pennsylvania.
Lawrence I SinowayPenn State Heart and Vascular Institute, Penn State University College of Medicine, Hershey, Pennsylvania.
Matthew D MullerPenn State Heart and Vascular Institute, Penn State University College of Medicine, Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Penn State Institutional Career Development CoreKL2TR002015 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VAN SCOY, LAUREN JODI · 2016 to 2025
$7.8M
American Heart Association-American Stroke Association 15PRE24470033NCATS NIH HHS KL2 TR002015NCATS NIH HHS UL1 TR002014NIH HHS UL1 TR002014
6 · The paper itself

Abstract

Emerging evidence suggests that sympathetic vasoconstriction is lower in young women. We hypothesized that increases in muscle sympathetic nerve activity (MSNA) during acute physiological stressors induce less vasoconstriction in young women compared to young men. Healthy young men (n = 10, 27 ± 1 years), young women (n = 12, 25 ± 1 years), and older women (n = 10, 63 ± 6 years) performed the cold pressor test (hand in ice for 2 min) and continuous hypoxia (10% O

Indexed as

AdolescentAdultAge FactorsCold TemperatureFemaleFemoral ArteryHemodynamicsHumansHypoxiaMaleMiddle AgedSex FactorsStress, PhysiologicalSympathetic Nervous SystemVasoconstrictionVasodilationBlood pressurefemoral blood flowmicroneurographysex differencessympathetic nervous systemvascular resistance

Identifiers

PMID30659773
PMCPMC6339536
OpenAlexW2910085647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.