Observational studyJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2019
Timing and Outcomes of Abdominal Surgery in Neutropenic Patients.
Observational study in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Return to intended oncologic therapy after treatment for cholecystitis in cancer patients.Surgery · 2026Article
- Postoperative complications in patients with chemotherapy-induced acute myeloid leukemia (Review).Oncology letters · 2026Review
- Frequency and Natural History of Emergency General Surgery Conditions in Cancer Patients: A SEER-medicare Population Analysis.Annals of surgery · 2026Article
- Preoperative cardiovascular evaluation in patients with cancer.Frontiers in cardiovascular medicine · 2026Review
- Building an integrated multidisciplinary care system for emergency surgery in abdominal cancer: a patient-centered perspective.Frontiers in surgery · 2026Article
- Clinical Outcome of Febrile Neutropenia and Associated Factors Among Adult Patients with Cancer Treated at Ethiopian Oncology Centers: A Retrospective Observational Study.Oncology and therapy · 2025Article
- Periprosthetic Infection after Endoprosthetic Reconstruction for Femoral Bone Metastases: Incidence and Risk Factors, a Single Center Study.Clinics in orthopedic surgery · 2025Article
- Multidisciplinary Treatment for Cecal Cancer and Metachronous Liver Metastases in a Patient with Primary Autoimmune Neutropenia.Surgical case reports · 2025Article
- Treatment for appendicitis in cancer patients on chemotherapy: a retrospective cohort study.Annals of surgical treatment and research · 2024Article
- Evaluation of Absolute Neutrophil Count in the Perioperative Setting of Sarcoma Resection.Advances in orthopedics · 2024Article
- Article
- Patients Undergoing Systemic Anti-Cancer Therapy Who Require Surgical Intervention: What Surgeons Need to Know.Cancers · 2023Review
- Neutropenic Enterocolitis: An Uncommon, but Fearsome Complication of Leukemia.Journal of hematology · 2023Review
- Pyomyositis presenting as myonecrosis secondary to methicillin-resistantProceedings (Baylor University. Medical Center) · 2022Article
- Gastrointestinal Surgical Emergencies in the Neutropenic Immunocompromised Patient.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Review
- Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management: A case report.World journal of clinical cases · 2021Article
- Combination of Common Problem in a Rare Disease: Right Iliac Fossa Pain in a Chronic Myeloid Leukemia Patient.Cureus · 2020Article
- Appendectomy in pediatric patients with synchronous oncologic diagnosis is safe: an analysis using the national surgical quality improvement project, pediatric.Pediatric surgery international · 2020Article
- Current Perspectives on Spinal Cord Stimulation for the Treatment of Cancer Pain.Journal of pain research · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery in neutropenic patients is challenging due to both atypical manifestations of common conditions and higher perioperative risk. We sought to describe the outcomes of neutropenic patients undergoing abdominal surgery and to identify factors contributing to morbidity and mortality.
methodsA retrospective chart review was performed for all patients neutropenic in the 24-hours prior to an abdominal operation at our institution between 1998 and 2017. The primary and secondary outcomes were 30-day mortality and morbidity, respectively. The chi-square test and two-tailed Student's t test were used for univariable comparisons (non-parametric tests used when appropriate). To determine the optimal threshold of absolute neutrophil count (ANC) to discriminate 30-day mortality, we maximized the Youden index (J).
resultsAmongst 237 patients, mortality was 11.8% (28/237) and morbidity 54.5% (130/237). Absolute neutrophil count < 500 cells/μL (50% vs. 20.6%, P < 0.01) and perforated viscus (35.7% vs. 14.8%, P = 0.01) were associated with mortality. Perforated viscus (25.4% vs. 7.5%) was also associated with morbidity. Urgent operations were associated with higher morbidity (63.6% vs 34.7%, P < 0.001) and mortality (16.4% vs 1.4%, P = 0.002) when compared to elective operations. Transfer from an outside hospital (22.3% vs. 11.2%, P = 0.02) and longer median time from admission to operation (2 days (IQR 0-6) vs. 1 day (IQR 0-3), P < 0.01) were associated with morbidity. An ANC threshold of 350 provided the best discrimination for mortality.
conclusionsElective surgery in the appropriately chosen neutropenic patient is relatively safe. For patients with obvious surgical pathology, we advocate for earlier operation and a lower threshold for surgical consultation in an effort expedite the diagnosis and necessary treatment.
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