ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Predicting cerebral edema in ischemic stroke patients.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Predictive Value of Machine Learning Models for Cerebral Edema Risk in Stroke Patients: A Meta-Analysis.Brain and behavior · 2025Pooled it
- White Matter Hyperintensities on Admission CT are Associated with Worse Outcomes But Not Cerebral Edema or Hemorrhagic Transformation After Large Vessel Occlusion Stroke.Neurocritical care · 2026Article
- White Matter Hyperintensities on Admission CT Are Associated with Worse Outcomes but not Cerebral Edema or Hemorrhagic Transformation after Large Vessel Occlusion Stroke.Research square · 2026Article
- Leveraging infarct topography for early warning: a robust model for predicting malignant cerebral edema after endovascular treatment in acute ischemic stroke.BMC medical imaging · 2026Article
- Development of the SIMPLE scoring system for predicting malignant brain edema in patients with large hemispheric infarction following acute ischemic stroke.Neurosurgical review · 2026Article
- Net water uptake as a predictor of the development of high-density lesions after endovascular treatment.Neuroradiology · 2026Article
- Hybrid machine learning for real-time prediction of edema trajectory in large middle cerebral artery stroke.NPJ digital medicine · 2025Article
- NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.CNS neuroscience & therapeutics · 2025Article
- Pre-thrombolysis serum sodium concentration is associated with post-thrombolysis symptomatic intracranial hemorrhage in ischemic stroke patients.Frontiers in neurology · 2024Article
- Predicting cerebral edema in patients with spontaneous intracerebral hemorrhage using machine learning.Frontiers in neurology · 2024Article
- Automated acute ischemic stroke lesion delineation based on apparent diffusion coefficient thresholds.Frontiers in neurology · 2023Article
- Predictors and Dynamic Nomogram to Determine the Individual Risk of Malignant Brain Edema After Endovascular Thrombectomy in Acute Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Development and Validation of Prediction Models for Severe Complications After Acute Ischemic Stroke: A Study Based on the Stroke Registry of Northwestern Germany.Journal of the American Heart Association · 2022Article
- Venous stroke-a stroke subtype that should not be ignored.Frontiers in neurology · 2022Review
- MRI Radiomics Features From Infarction and Cerebrospinal Fluid for Prediction of Cerebral Edema After Acute Ischemic Stroke.Frontiers in aging neuroscience · 2022Article
- Medical management of cerebral edema in large hemispheric infarcts.Frontiers in neurology · 2022Review
- Hyperdense artery sign, symptomatic infarct swelling and effect of alteplase in acute ischaemic stroke.Stroke and vascular neurology · 2021Article
- The Survival Status and Predictors of Mortality Among Stroke Patients at North West Ethiopia.Risk management and healthcare policy · 2021Article
- Evaluation and Prediction of Post-stroke Cerebral Edema Based on Neuroimaging.Frontiers in neurology · 2021Review
- Venous thromboembolism prevention with low molecular weight heparin may reduce hemorrhagic transformation in acute ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo produce a scoring system for predicting the development of edema in ischemic stroke patients without edema on admission.
methodsThis retrospective study included 572 ischemic stroke patients (73.3 ± 13.0 years, 300 male) without signs of cerebral edema on the first CT scan, which was performed on admission. Another scan was normally performed 3 days later, and subsequently whenever needed. Edema was defined as cerebral hypodensity with compression of lateral ventricles. The main clinical, laboratory, and instrumental variables obtained during the first 24 h were related to the appearance of edema on the CT scans performed after the first one.
resultsCerebral edema occurred in 158 patients (27.6%) after a median time of 4 days. The variables independently associated with edema development were (odds ratio, 95% CI) the following: (1) total anterior circulation syndrome (4.20, 2.55-6.93; P < 0.0001), (2) hyperdense appearance of middle cerebral artery (4.12, 2.03-8.36; P = 0.0001), (3) closed eyes (2.53, 1.39-4.60; P = 0.002), (4) vomiting (3.53, 1.45-8.60; P = 0.006), (5) lacunar cerebral syndrome (0.36, 0.17-0.77; P = 0.008); and (6) white matter lesions (0.53, 0.33-0.86; P = 0.01). Counting one positive point for the first four variables and one negative point for the last two variables, a scoring system (E-score) was built. Cerebral edema could be predicted when the score was ≥ 1 (positive predictive value 61.6%, specificity 85.3%, sensitivity 62.0%). The area under the receiver operating characteristic curve was 0.78.
conclusionsIn ischemic stroke patients, six variables obtained during the first 24 h of hospitalization were predictive of subsequent cerebral edema development.
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