ArticleJournal of ophthalmic inflammation and infection2019
The ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis.
Article in Journal of ophthalmic inflammation and infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Case 23: A 26-Year-Old Man Presenting With Right-Eye Visual Disturbances.Journal of Korean medical science · 2026Article
- Longitudinal Trend in Hospital-Wide Syphilis Testing and Clinical Characteristics of Syphilis Requiring Treatment.Pathogens (Basel, Switzerland) · 2025Article
- Could ceftriaxone be a viable alternative to penicillin for the treatment of ocular syphilis?Antimicrobial agents and chemotherapy · 2024Article
- Clinical features and incidence of visual improvement following systemic antibiotic treatment in patients with syphilitic uveitis.Scientific reports · 2022Article
- Spontaneous hyphema associated with ocular syphilis.Journal of ophthalmic inflammation and infection · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSyphilitic uveitis is reemerging globally, may lead to any type of intraocular inflammation, and is potentially sight-threatening. We aim to characterize clinical features and prognostic factors in patients with syphilitic posterior uveitis.
methodsRetrospective chart review at two tertiary university-based referral centers in Brazil. Clinical data, laboratory results, and treatment outcomes were analyzed. Statistical analysis was performed using Fisher's exact test for categorical variables and Mann-Whitney U test for continuous variables.
resultsForty-four patients (81 eyes) were consecutively diagnosed with syphilitic posterior uveitis between March 2011 and April 2013.Thirty-one were male (70.5%) and the mean age was 43.8 years (range 15-81). HIV confection was disclosed in 12 patients (29.3%). The most prevalent finding was vitritis (85.2%), followed by retinal involvement (76.4%) and optic disc abnormalities (63.5%). After treatment, mean visual acuity improved from 1.2 (20/320) to 0.6 (20/80; median 20/30), but 19 eyes (23.5%) persisted with ≤ 1.0 (20/200). Factors associated with final visual acuity ≤ 1.0 despite therapy were prior use of systemic corticosteroids (p = 0.001), higher Venereal Disease Research Laboratory titers (p = 0.004), longer duration of symptoms (p = 0.024), and worse initial VA (p < 0.001).
conclusionsSyphilitic uveitis is reemerging. Delayed diagnosis and inadvertent use of systemic corticosteroids are potentially modifiable prognostic factors to be considered for possibly improving outcomes.
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