ArticleEuropean child & adolescent psychiatry2019
Antidepressant prescription patterns and CNS polypharmacy with antidepressants among children, adolescents, and young adults: a population-based study in Sweden.
Article in European child & adolescent psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Trends in age-sex-specific prevalence and incidence of antidepressant dispensation in the Nordic countries: a systematic review.British journal of clinical pharmacology · 2026Pooled it
- Change of antidepressant utilization in children, adolescents and young adults in Europe before and during the COVID-19 pandemic: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- Risk of Suicidal Behaviors and Antidepressant Exposure Among Children and Adolescents: A Meta-Analysis of Observational Studies.Frontiers in psychiatry · 2022Pooled it
- Social deprivation in adolescence and risk of depression in young adulthood: a longitudinal analysis of linked administrative data from Northern Ireland.Social psychiatry and psychiatric epidemiology · 2026Article
- Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan.Annals of general psychiatry · 2026Article
- Comorbidities and comedication among individuals in treatment for ADHD: a Danish nationwide study.BMC psychiatry · 2026Article
- Patterns of Antidepressant and Anxiolytic Use and Spending in 14 European Countries (2012-2021): A Comprehensive Time Series Analysis.Health services insights · 2024Article
- Use of Antidepressant and Anxiolytic Drugs in Scandinavian Countries between 2006 and 2021: A Prescription Database Study.Depression and anxiety · 2024Article
- Cultural contexts of adolescent anxiety: Paradox, ambivalence, and disjuncture.Social sciences & humanities open · 2024Article
- Drug Safety and Suicidality Risk of Chronic Pain Medications.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Psychotropic Medication Use in Children and Adolescents With Type 1 Diabetes.JAMA network open · 2023Article
- Parental death and initiation of antidepressant treatment in surviving children and youth: a national register-based matched cohort study.EClinicalMedicine · 2023Article
- Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases.BMC pharmacology & toxicology · 2023Article
- Anticholinergic Medication and Caries Status Predict Xerostomia under 65.Dentistry journal · 2023Article
- Pediatric Psychotropic Polypharmacy: An Evaluation of the Correlates and Prevalence Across Assessment Cycles in the National Health and Nutrition Examination Survey.Journal of child and adolescent psychopharmacology · 2022Article
- Use of central nervous system drugs in combination with selective serotonin reuptake inhibitor treatment: A Bayesian screening study for risk of suicidal behavior.Frontiers in psychiatry · 2022Article
- Comedication and Polypharmacy With ADHD Medications in Adults: A Swedish Nationwide Study.Journal of attention disorders · 2021Article
- Temporal trends in annual incidence rates for psychiatric disorders and self-harm among children and adolescents in the UK, 2003-2018.BMC psychiatry · 2021Article
- Initiation of antidepressant use among refugee and Swedish-born youth after diagnosis of a common mental disorder: findings from the REMAIN study.Social psychiatry and psychiatric epidemiology · 2021Article
- Clinical Effectiveness of Training for Awareness Resilience and Action Online Compared to Standard Treatment for Adolescents and Young Adults With Depression: Study Protocol and Analysis Plan for a Pragmatic, Multi-Center Randomized Controlled Superiority Trial.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examines trends in antidepressant drug dispensations among young people aged 0-24 years in Sweden during the period 2006-2013, as well as prescription patterns and central nervous system (CNS) polypharmacy with antidepressants. Using linkage of Swedish national registers, we identified all Swedish residents aged 0-24 years that collected at least one antidepressant prescription (here defined as antidepressant users) between 1 January 2006 and 31 December 2013 (n = 174,237), and categorized them as children (0-11 years), adolescents (12-17 years), and young adults (18-24 years). Prevalence of antidepressant dispensation rose from 1.4 to 2.1% between 2006 and 2013, with the greatest relative increase in adolescents [by 97.8% in males (from 0.6 to 1.3%) and by 86.3% in females (from 1.1 to 2.1%)]. Most individuals across age categories were prescribed selective serotonin reuptake inhibitors, received their prescriptions from psychiatric specialist care, and had treatment periods of over 12 months. Prevalence of CNS polypharmacy (dispensation of other CNS drug classes in addition to antidepressants) increased across age categories, with an overall increase in prevalence from 52.4% in 2006 to 62.1% in 2013. Children experienced the largest increase in polypharmacy of three or more psychotropic drug classes (4.4-10.1%). Anxiolytics, hypnotics, and sedatives comprised the most common additional CNS drug class among persons who were prescribed antidepressants. These findings show that the dispensation of antidepressants among the young is prevalent and growing in Sweden. The substantial degree of CNS polypharmacy in young patients receiving antidepressants requires careful monitoring and further research into potential benefits and harms.
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