ArticleAnnals of intensive care2019
Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children.
Article in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care.Frontiers in oncology · 2025Article
- Monitoring lung recruitability during recruitment maneuvers in children with respiratory failure on ECMO using electrical impedance tomography: case report.Frontiers in pediatrics · 2025Article
- Gas transport mechanisms during high-frequency ventilation.Respiratory research · 2024Review
- High-Flow Oscillatory Ventilation: A Possible Therapeutic Option for Pediatric Patients with Cardiovascular Diseases.Pediatric reports · 2024Review
- A Master Protocol Template for Pediatric ARDS Studies.Respiratory care · 2024Article
- Lung behavior during a staircase high-frequency oscillatory ventilation recruitment maneuver.Intensive care medicine experimental · 2024Article
- High-Frequency Percussive Ventilation in Viral Bronchiolitis.Respiratory care · 2022Article
- Acute Respiratory Distress Syndrome Management in Pediatric Intensive Care Units in Turkey: A Prospective Survey.Turkish archives of pediatrics · 2022Article
- Tidal volume significantly affects oxygenation in healthy pigs during high-frequency oscillatory ventilation compared to conventional ventilation.Biomedical engineering online · 2022Article
- The Physiological Basis of High-Frequency Oscillatory Ventilation and Current Evidence in Adults and Children: A Narrative Review.Frontiers in physiology · 2022Review
- A narrative review of advanced ventilator modes in the pediatric intensive care unit.Translational pediatrics · 2021Review
- Performance of acute respiratory distress syndrome definitions in a high acuity paediatric intensive care unit.Respiratory research · 2021Article
- Mechanical Ventilation in Pediatric and Neonatal Patients.Frontiers in physiology · 2021Review
- Physiologic responses to a staircase lung volume optimization maneuver in pediatric high-frequency oscillatory ventilation.Annals of intensive care · 2020Article
- Response to the authors.Annals of intensive care · 2020Article
- Letter to the Editor: Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children.Annals of intensive care · 2020Article
- High-frequency oscillatory ventilation in a tertiary paediatric intensive care unit in an academic hospital in Johannesburg, South Africa.The Southern African journal of critical care : the official journal of the Critical Care Society · 2019Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-frequency oscillatory ventilation (HFOV) is a common but unproven management strategy in paediatric critical care. Oscillator settings have been traditionally guided by patient age and/or weight rather than by lung mechanics, thereby potentially negating any beneficial effects. We have adopted an open-lung HFOV strategy based on a corner frequency approach using an initial incremental-decremental mean airway pressure titration manoeuvre, a high frequency (8-15 Hz), and high power to initially target a proximal pressure amplitude (∆P
methodsWe reviewed prospectively collected data on patients < 18 years of age who were managed with HFOV for acute respiratory failure. We measured metrics for oxygenation, ventilation, and haemodynamics as well as the use of sedative-analgesic medications and neuromuscular blocking agents.
resultsData from 115 non-cardiac patients were analysed, of whom 53 had moderate-to-severe paediatric acute respiratory distress syndrome (PARDS). Sixteen patients (13.9%) died. Frequencies≥ 8 Hz and high ∆P
conclusionsThis is the first study reporting the feasibility of an alternative, individualized, physiology-based open-lung HFOV strategy targeting high F and high ∆P
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