Evidence map›Paper›PMID 30659270›Full record

ArticlePediatric research2019

MeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome.

Chang-Yien Chan, Lourdes Paula Resontoc, Md Abdul Qader, Yiong-Huak Chan, Isaac Desheng Liu, Perry Yew-Weng Lau, Mya Than, Wee-Song Yeo, Alwin Hwai-Liang Loh, Puay-Hoon Tan and 5 more

Abstract read
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In one paragraph

Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. c-Src is in the effector pathway linking uPAR and podocyte injury.The Journal of clinical investigation · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chang-Yien Chan *Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.ORCID http://orcid.org/0000-0001-5841-1417
Lourdes Paula Resontoc *Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Md Abdul QaderDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Yiong-Huak ChanBiostatistics Unit, National University of Singapore, Singapore, Singapore.
Isaac Desheng LiuDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Perry Yew-Weng LauDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Mya ThanDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Wee-Song YeoDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Alwin Hwai-Liang LohDepartment of Anatomic Pathology, Singapore General Hospital, Singapore, Singapore.
Puay-Hoon TanDepartment of Anatomic Pathology, Singapore General Hospital, Singapore, Singapore.
Changli WeiDepartment of Medicine, Rush University Medical Center, Chicago, IL, USA.
Jochen ReiserDepartment of Medicine, Rush University Medical Center, Chicago, IL, USA.
Subhra K BiswasSingapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
Kar-Hui NgDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Hui-Kim YapDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore. paeyaphk@nus.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA lack of consensus exists as to the timing of kidney biopsy in children with steroid-dependent nephrotic syndrome (SDNS) where minimal change disease (MCD) predominates. This study aimed at examining the applicability of a biomarker-assisted risk score model to select SDNS patients at high risk of focal segmental glomerulosclerosis (FSGS) for biopsy.

methodsFifty-five patients with SDNS and biopsy-proven MCD (n = 40) or FSGS (n = 15) were studied. A risk score model was developed with variables consisting of age, sex, eGFR, suPAR levels and percentage of CD8

resultsPlasma suPAR levels in FSGS patients were significantly higher, while percentage of CD45RO

conclusionA suPAR and CD8

Indexed as

BiopsyAdolescentAnti-Inflammatory AgentsCase-Control StudiesChildChild, PreschoolFemaleGlomerulosclerosis, Focal SegmentalHumansKidneyLymphocyte SubsetsMaleNephrotic SyndromePrednisoloneReceptors, Urokinase Plasminogen ActivatorRisk AssessmentAnti-Inflammatory AgentsPrednisoloneReceptors, Urokinase Plasminogen Activator

Identifiers

PMID30659270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.