Evidence map›Paper›PMID 30659254›Full record

ArticleInternational journal of obesity (2005)2019

In utero dioxin exposure and cardiometabolic risk in the Seveso Second Generation Study.

Marcella Warner, Stephen Rauch, Jennifer Ames, Paolo Mocarelli, Paolo Brambilla, Stefano Signorini, Brenda Eskenazi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  5. Human embryonic stem cells as anWorld journal of stem cells · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marcella WarnerCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA. mwarner@berkeley.edu.
Stephen RauchCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Jennifer AmesCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Paolo MocarelliDepartment of Laboratory Medicine, School of Medicine, Hospital of Desio, University of Milano-Bicocca, Desio-Milano, Italy.
Paolo BrambillaDepartment of Laboratory Medicine, School of Medicine, Hospital of Desio, University of Milano-Bicocca, Desio-Milano, Italy.
Stefano SignoriniDepartment of Laboratory Medicine, School of Medicine, Hospital of Desio, University of Milano-Bicocca, Desio-Milano, Italy.
Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Center for Environmental Health · USUniversity of Milano-Bicocca · IT

Funding

In Utero Dioxin Exposure in Seveso, Italy and Health of the Second GenerationR01ES007171 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1996 to 2017
$7.1M
VIROLOGY AND CHRONIC INFECTIONP30ES001896 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1985 to 2003
$4.7M
Gene-dioxin interaction and low birth weight in a highly exposed European cohortF31ES026488 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI AMES, JENNIFER LISA · 2016 to 2018
$95k
ENDOMETRIOSIS AND DIOXIN EXPOSURE OF RESIDENTS OF SEVESOF06TW002075 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1994 to 1994
–
FIC NIH HHS F06 TW002075NIEHS NIH HHS F31 ES026488NIEHS NIH HHS P30 ES001896NIEHS NIH HHS R01 ES007171
6 · The paper itself

Abstract

BACKGROUND/

objectivesIn utero exposure to endocrine-disrupting compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may alter risk of obesity and related metabolic disease later in life. We examined the relationship of prenatal exposure to TCDD with obesity and metabolic syndrome (MetS) in children born to a unique cohort of TCDD-exposed women resulting from a 1976 explosion in Seveso, Italy. SUBJECTS/

methodsIn 2014, nearly 40 years after the explosion, we enrolled 611 post-explosion offspring, 2 to 39 years of age, in the Seveso Second Generation Study. In utero TCDD exposure was defined primarily as TCDD concentration measured in maternal serum collected soon after the explosion and alternately as TCDD estimated at pregnancy. We measured height, weight, waist circumference, body fat, blood pressure, and fasting blood levels of lipids and glucose, which were combined to assess body mass index (BMI) and MetS.

resultsChildren (314 female, 297 male) averaged 23.6 (±6.0) years of age. Among the 431 children ≥18 years, a 10-fold increase in initial maternal TCDD concentration was inversely associated with BMI in daughters (adj-β = -0.99 kg/m

conclusionsThese results suggest prenatal TCDD exposure alters cardiometabolic endpoints in a sex-specific manner. In daughters, in utero TCDD is inversely associated with adiposity measures. In sons, in utero TCDD is associated with increased risk for MetS.

Indexed as

Polychlorinated DibenzodioxinsAdolescentAdultBlood PressureBody SizeChildChild, PreschoolCohort StudiesFemaleHumansItalyMaleMaternal ExposureMetabolic SyndromePregnancyYoung AdultPolychlorinated Dibenzodioxins

Identifiers

PMID30659254
PMCPMC6639155
OpenAlexW2909297041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.