ArticleScientific reports2019
Prediction of mortality in Chinese very old people through the frailty index based on routine laboratory data.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of frailty and mortality risk in community-dwelling older adults: a systematic review and meta-analysis of 59 international prospective cohort studies.BMC public health · 2026Pooled it
- The frailty index based on laboratory test data as a tool to investigate the impact of frailty on health outcomes: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Frailty as a mortality predictor in older adults with COVID-19: A systematic review and meta-analysis of cohort studies.Geriatric nursing (New York, N.Y.)Pooled it
- Investigating aging trajectories and determinants in Northern Italy through the Novara cohort study.Scientific reports · 2025Article
- Relationship between the laboratory test-based frailty index and overall mortality in critically ill patients with acute pancreatitis: a retrospective study based on the MIMIC-IV database.Frontiers in medicine · 2025Article
- Association between frailty index based on laboratory tests and all-cause mortality in critically ill patients with heart failure.ESC heart failure · 2024Observational
- The longitudinal study of the relationship between social participation pattern and depression symptoms in frail older adults.Frontiers in psychiatry · 2024Article
- Prognostic significance of frailty in hospitalized elderly patients with community-acquired pneumonia: a retrospective cohort study.BMC geriatrics · 2023Article
- Prevalence of frailty and prediction of mortality in Chinese cancer patients using a frailty index-based clinical algorithm-A multicentre study.Cancer medicine · 2021Observational
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- The association between preoperative modified frailty index and postoperative complications in Chinese elderly patients with hip fractures.BMC geriatrics · 2021Article
- Complementing chronic frailty assessment at hospital admission with an electronic frailty index (FI-Laboratory) comprising routine blood test results.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Frailty and aging medicine.Aging medicine (Milton (N.S.W)) · 2019Article
- Frailty Index was Associated With Adverse Outcomes in Admitted Elderly Patients With Type 2 Diabetes Mellitus.Inquiry : a journal of medical care organization, provision and financingArticle
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The increased risk of death in older adults can be successfully identified through frailty index (FI), based on comprehensive geriatric assessment data and self-reported data from the accumulated deficit, although the method depending on routine laboratory data (FI-LAB) remains uncertain. In the current study, the capacity of FI-LAB in evaluating the risk of mortality in a very old Chinese community cohort was analyzed. The 90-year- and above old individuals from a Dujiangyan community in Sichuan Province, China, who had completed a health assessment at baseline (in 2005) and whose laboratory data were analyzed (n = 736) from cumulative data from the Project of Longevity and Aging. The FI-LAB data was constructed from routine laboratory data and calculated as the ratio of abnormal factors in 22 variables (including red blood cells, white blood cells, and alanine transaminase) that can be assessed through blood tests. The multivariable Cox regression was used to evaluate the effect of frailty on death. In the four-year follow-up, 53.5% of the 736 participants (age = 93.6 ± 3.4 years; 67.5% women), were reported dead. The FI-LAB mean baseline value was 0.21 (standard deviation = 0.10; range = 0 to 0.55). Frailty (after adjusting for gender, age, and other confounders) could be directly correlated with increased death risk, with a hazard ratio of 1.31 (95% confidence interval (CI): 1.07-1.61) in comparison with those without frailty among the individuals. Frailty as defined by FI-LAB, established only on routine laboratory data, indicates a significant death risk in the very old people.
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