Evidence map›Paper›PMID 30659245›Full record

ReviewNature reviews. Rheumatology2019

Neuropsychiatric lupus: new mechanistic insights and future treatment directions.

Noa Schwartz, Ariel D Stock, Chaim Putterman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

229 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  12. The theory of the inflammatory ecosystem.Science China. Life sciences · 2026
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169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noa SchwartzDivision of Rheumatology, Hospital for Special Surgery, New York, NY, USA.
Ariel D StockDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Chaim PuttermanDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. chaim.putterman@einstein.yu.edu.ORCID http://orcid.org/0000-0002-3204-6068

Funding

GENETIC AND BIOCHEMICAL MECHANISMS OF REGULATIONT32GM007122 · NIGMS · BRANDEIS UNIVERSITY · PI LOVETT, SUSAN THOMAS · 1985 to 2020
$7.5M
The role of TWEAK and Fn14 in the Pathogenesis and Treatment of NeuropsychiatricR01AR065594 · NIAMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PUTTERMAN, CHAIM · 2014 to 2018
$2.4M
HSS Research Institute Rheumatology TrainingT32AR071302 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ALESSANDRA B PERNIS, Jane E Salmon · 2017 to 2026
$2.3M
NIAMS NIH HHS R01 AR065594NIAMS NIH HHS T32 AR071302NIGMS NIH HHS T32 GM007122
6 · The paper itself

Abstract

Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS manifestations of SLE are diverse and have a broad spectrum of severity and prognostic implications. Patients with NPSLE typically present with nonspecific symptoms, such as headache and cognitive impairment, but might also experience devastating features, such as memory loss, seizures and stroke. Some features of NPSLE, in particular those related to coagulopathy, have been characterized and an evidence-based treatment algorithm is available. The cognitive and affective manifestations of NPSLE, however, remain poorly understood. Various immune effectors have been evaluated as contributors to its pathogenesis, including brain-reactive autoantibodies, cytokines and cell-mediated inflammation. Additional brain-intrinsic elements (such as resident microglia, the blood-brain barrier and other neurovascular interfaces) are important facilitators of NPSLE. As yet, however, no unifying model has been found to underlie the pathogenesis of NPSLE, suggesting that this disease has multiple contributors and perhaps several distinct aetiologies. This heterogeneity presents a challenge for clinicians who have traditionally relied on empirical judgement in choosing treatment modalities for patients with NPSLE. Improved understanding of this manifestation of SLE might yield further options for managing this disease.

Indexed as

AnimalsHumansLupus Vasculitis, Central Nervous System

Identifiers

PMID30659245
PMCPMC8023338

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.