ArticleScientific reports2019
Klebsiella pneumoniae prevents spore germination and hyphal development of Aspergillus species.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- First Case of Cutaneous Coinfection withDiagnostics (Basel, Switzerland) · 2026Article
- Identification of a fungal antibacterial endopeptidase that cleaves peptidoglycan.EMBO reports · 2025Article
- Aspergillus fumigatus escape mechanisms from its harsh survival environments.Applied microbiology and biotechnology · 2024Review
- Integrated multi-omics identifies pathways governing interspecies interaction between A. fumigatus and K. pneumoniae.Communications biology · 2024Article
- Cross interaction between bacterial and fungal microbiota and their relevance to human health and disease: mechanistic pathways and prospective therapy.Bioscience of microbiota, food and health · 2024Review
- Interactions between Bacteria andJournal of fungi (Basel, Switzerland) · 2023Review
- Exposure ofJournal of fungi (Basel, Switzerland) · 2023Article
- Article
- Metabolic modeling of the International Space Station microbiome reveals key microbial interactions.Microbiome · 2022Article
- In Vitro Investigation of the Impact of Bacterial-Fungal Interaction on Carbapenem-ResistantMolecules (Basel, Switzerland) · 2022Article
- Coinfection with HypervirulentInfection and drug resistance · 2022Article
- Steroid-Functionalized Imidazolium Salts with an Extended Spectrum of Antifungal and Antibacterial Activity.International journal of molecular sciences · 2021Article
- A Shifted Composition of the Lung Microbiota Conditions the Antifungal Response of Immunodeficient Mice.International journal of molecular sciences · 2021Article
- Bacterial Interactions withMicroorganisms · 2021Review
- Culturable Bacterial Endophytes Associated With Shrubs Growing Along the Draw-Down Zone of Lake Bogoria, Kenya: Assessment of Antifungal Potential AgainstFrontiers in plant science · 2021Article
- Symbiosis and Dysbiosis of the Human Mycobiome.Frontiers in microbiology · 2021Review
- Pathogenetic Impact of Bacterial-Fungal Interactions.Microorganisms · 2019Review
- Fungal-Bacterial Interactions in Health and Disease.Pathogens (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different bacteria and fungi live as commensal organisms as part of the human microbiota, but shifts to a pathogenic state potentially leading to septic infections commonly occur in immunocompromised individuals. Several studies have reported synergistic or antagonistic interactions between individual bacteria and fungi which might be of clinical relevance. Here, we present first evidence for the interaction between Klebsiella pneumoniae and several Aspergillus species including A. fumigatus, A. terreus, A. niger and A. flavus which cohabit in the lungs and the intestines. Microbiological and molecular methods were employed to investigate the interaction in vitro, and the results indicate that Klebsiella pneumoniae is able to prevent Aspergillus spp. spore germination and hyphal development. The inhibitory effect is reversible, as demonstrated by growth recovery of Aspergillus spp. upon inhibition or elimination of the bacteria, and is apparently dependent on the physical interaction with metabolically active bacteria. Molecular analysis of Klebsiella-Aspergillus interaction has shown upregulation of Aspergillus cell wall-related genes and downregulation of hyphae-related genes, suggesting that Klebsiella induces cell wall stress response mechanisms and suppresses filamentous growth. Characterization of polymicrobial interactions may provide the basis for improved clinical management of mixed infections by setting the stage for appropriate diagnostics and ultimately for optimized treatment strategies.
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Registered trials
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