ArticleNature communications2019
Time-dependent assessment of stimulus-evoked regional dopamine release.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events.Science advances · 2026Article
- Untangling dopamine and glutamate in the ventral tegmental area.bioRxiv : the preprint server for biology · 2025Article
- Novel voxelwise residual analysis of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Deep brain stimulation by blood-brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound.Nature biomedical engineering · 2023Article
- Article
- Cortical D1 and D2 dopamine receptor availability modulate methylphenidate-induced changes in brain activity and functional connectivity.Communications biology · 2022Article
- Functional dynamics of dopamine synthesis during monetary reward and punishment processing.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting.Nature neuroscience · 2021Article
- The chemical tools for imaging dopamine release.Cell chemical biology · 2021Review
- Recent Advances in In Vivo Neurochemical Monitoring.Micromachines · 2021Review
- Evaluation of electrochemical methods for tonic dopamine detectionTrends in analytical chemistry : TRAC · 2020Article
- Dopamine release, diffusion and uptake: A computational model for synaptic and volume transmission.PLoS computational biology · 2020Article
- High long-term test-retest reliability for extrastriatalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice.The Journal of clinical investigation · 2020Article
- Needle-type organic electrochemical transistor for spatially resolved detection of dopamine.Mikrochimica acta · 2020Article
- Regional Variation in Striatal Dopamine Spillover and Release Plasticity.ACS chemical neuroscience · 2020Article
- Combining designer receptors exclusively activated by designer drugs and neuroimaging in experimental models: A powerful approach towards neurotheranostic applications.British journal of pharmacology · 2020Review
- Methods for Quantifying Neurotransmitter Dynamics in the Living Brain With PET Imaging.Frontiers in physiology · 2020Review
- In vivo functional diversity of midbrain dopamine neurons within identified axonal projections.eLife · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
To date, the spatiotemporal release of specific neurotransmitters at physiological levels in the human brain cannot be detected. Here, we present a method that relates minute-by-minute fluctuations of the positron emission tomography (PET) radioligand [11C]raclopride directly to subsecond dopamine release events. We show theoretically that synaptic dopamine release induces low frequency temporal variations of extrasynaptic extracellular dopamine levels, at time scales of one minute, that can evoke detectable temporal variations in the [11C]raclopride signal. Hence, dopaminergic activity can be monitored via temporal fluctuations in the [11C]raclopride PET signal. We validate this theory using fast-scan cyclic voltammetry and [11C]raclopride PET in mice during chemogenetic activation of dopaminergic neurons. We then apply the method to data from human subjects given a palatable milkshake and discover immediate and-for the first time-delayed food-induced dopamine release. This method enables time-dependent regional monitoring of stimulus-evoked dopamine release at physiological levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.