ArticleTranslational psychiatry2019
The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Lipid levels and the risk of dementia: A dose-response meta-analysis of prospective cohort studies.Annals of clinical and translational neurology · 2022Pooled it
- Lipid-lowering Drugs and Neurocognitive Function: A Systematic Review.In vivo (Athens, Greece)Pooled it
- Cholesterol efflux capacity of high-density lipoprotein was not associated with cognitive decline and brain structures in older people with diabetes mellitus.Journal of diabetes investigation · 2022Trial
- Associations of work-related stress and total sleep time with cholesterol levels in an occupational cohort of Japanese office workers.Journal of occupational health · 2021Trial
- Associations of plasma HDL subclasses with incident dementia risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- HDL cholesterol indicates neurodegenerative vulnerability in dementia with lewy bodies.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Oxylipin composition of high-density lipoprotein is altered in men and Hispanic adults with mild cognitive impairment.Journal of lipid research · 2026Article
- Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.European archives of psychiatry and clinical neuroscience · 2026Article
- Exploring the intricate interplay between metabolic abnormalities and multidimensional cognitive impairment in stable schizophrenia patients.Translational psychiatry · 2026Observational
- Relationship of the TG/HDL Ratio With Cognition Function in Older Adults (≥ 60 Years): A Cross-Sectional Analysis of NHANES 2011-2014.Health science reports · 2025Article
- Lipoprotein levels and statin treatment related to dementia and cognitive decline in individuals with type 2 diabetes: an observational analysis from the ADVANCE study.Cardiovascular diabetology · 2025 · on this mapObservational
- Causal cardiovascular risk factors for dementia: insights from observational and genetic studies.Cardiovascular research · 2025Review
- Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals.JAMA network open · 2025Article
- DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts.American journal of human genetics · 2025Article
- Predicting Mild Cognitive Impairment in Type 2 Diabetes: A Machine Learning Approach.Journal of diabetes research · 2025Article
- Association between platelet-to-high-density lipoprotein cholesterol ratio and cognitive function in older americans: insights from a cross-sectional study.Scientific reports · 2024Article
- The Association Between Cardiometabolic Risk and Cognitive Function Among Older Americans and Chinese.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Methylome-wide studies of six metabolic traits.medRxiv : the preprint server for health sciences · 2024Article
- Cholesterol-metabolism, plant sterols, and long-term cognitive decline in older people - Effects of sex and APOEe4.iScience · 2024Article
- Association between obesity, physical activity, and cognitive decline in Chinese middle and old-aged adults: a mediation analysis.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A third of dementia cases could be attributable to modifiable risk-factors. Midlife high-density lipoprotein cholesterol (HDL-C) is a measure which could help identify individuals at reduced risk of developing age-related cognitive decline. The Japan Public Health Centre-based prospective (JPHC) Study is a large population-based cohort which started in 1990. This study included 1299 participants from Saku area in Nagano prefecture. Participants had HDL-C measured in 1995-1996, and underwent a mental health screening in 2014-2015. Of these, 1114 participants were included in MCI analyses, and 781 participants were included in dementia analyses. Logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) for the association between HDL-C quartiles and MCI and dementia, respectively. For dementia analysis, quartiles 2-4 were collapsed due to low number of cases. Missing data was addressed through multiple imputations. There were 386 cases of MCI and 53 cases of dementia. Compared to the lowest HDL-C quartile, the highest HDL-C quartile was significantly inversely associated with MCI (OR = 0.47, 95% CI, 0.28-0.79) in the multivariable analysis. High HDL-C (quartiles 2-4) was inversely associated with dementia compared to low HDL-C (quartile 1) (OR = 0.37, 95% CI, 0.16-0.88). This study has found that high midlife HDL-C levels are inversely associated with both late-life MCI and dementia in a Japanese population.
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