ArticleTranslational psychiatry2019
A validation of the diathesis-stress model for depression in Generation Scotland.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.Translational psychiatry · 2026Pooled it
- Methylome-Wide Association Studies of Physical Injury Stratified by Depression Status Assesses Exposure by Diagnosis Effects in Oxytocin Signaling and Synaptic Plasticity.Biological psychiatry global open science · 2026Article
- The relationship between impulsivity and non-suicidal self-injury in adolescents: the chain-mediated effects of parenting style and distress tolerance.Frontiers in psychiatry · 2026Article
- Neuroimmune Interactions in Stress and Depression: Exploring the Molecular and Cellular Mechanisms within the Neuroinflammation-depression Nexus.Current medicinal chemistry · 2026Review
- Parental Mental Health and Suicidal Behavior as Predictors of Adolescent Suicidal Ideation and Attempts: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- The roles of adverse childhood experiences and genetic liability in risk for suicidal thoughts and behaviors: A factor analytic approach.Journal of affective disorders · 2025Article
- Associations and Interactions Between Neuroticism, Adverse Life Events and Health Anxiety: Results From a Large Representative Cohort.Clinical psychology in Europe · 2025Article
- Explaining factors influencing students' depression with a deep learning approach.Frontiers in psychology · 2025Article
- Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression.Molecular psychiatry · 2024Article
- Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.Nature genetics · 2024Article
- Effects of lockdowns on neurobiological and psychometric parameters in unipolar depression during the COVID-19 pandemic.Translational psychiatry · 2024Article
- A scoping review of the impact of eco-distress and coping with distress on the mental health experiences of climate scientists.Frontiers in psychology · 2024Article
- The relationship between disease-specific psychosocial stressors and depressive symptoms in Huntington's disease.Journal of neurology · 2024Article
- Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample.Frontiers in psychiatry · 2024Article
- The Relationship of Rejection Sensitivity to Depressive Symptoms in Adolescence: The Indirect Effect of Perceived Social Acceptance by Peers.Behavioral sciences (Basel, Switzerland) · 2023Article
- Anxiety, depression, and their comorbidity among Chinese college students during the COVID-19 lockdown in the post-epidemic era: an online cross-sectional survey.BMC psychiatry · 2023Article
- The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.Genes, brain, and behavior · 2023Article
- AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models.Translational psychiatry · 2023Article
- Examining the shared etiology of psychopathology with genome-wide association studies.Physiological reviews · 2023Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Depression has well-established influences from genetic and environmental risk factors. This has led to the diathesis-stress theory, which assumes a multiplicative gene-by-environment interaction (GxE) effect on risk. Recently, Colodro-Conde et al. empirically tested this theory, using the polygenic risk score for major depressive disorder (PRS, genes) and stressful life events (SLE, environment) effects on depressive symptoms, identifying significant GxE effects with an additive contribution to liability. We have tested the diathesis-stress theory on an independent sample of 4919 individuals. We identified nominally significant positive GxE effects in the full cohort (R
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.