Evidence map›Paper›PMID 30659150›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Illuminating spatial A-to-I RNA editing signatures within the

Anne L Sapiro, Anat Shmueli, Gilbert Lee Henry, Qin Li, Tali Shalit, Orly Yaron, Yoav Paas, Jin Billy Li, Galit Shohat-Ophir

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 65 citations in OpenAlex.

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  8. ADARs mediate distinct RNA editing activity and gene regulation in thebioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anne L SapiroDepartment of Genetics, Stanford University, Stanford, CA 94305.
Anat ShmueliThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002 Ramat-Gan, Israel.
Gilbert Lee HenryJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.
Qin LiDepartment of Genetics, Stanford University, Stanford, CA 94305.
Tali ShalitIsrael National Center for Personalized Medicine, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Orly YaronThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002 Ramat-Gan, Israel.
Yoav PaasThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002 Ramat-Gan, Israel.
Jin Billy LiDepartment of Genetics, Stanford University, Stanford, CA 94305; jin.billy.li@stanford.edu galit.ophir@biu.ac.il.
Galit Shohat-OphirThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002 Ramat-Gan, Israel; jin.billy.li@stanford.edu galit.ophir@biu.ac.il.ORCID 0000-0003-1246-1827
Bar-Ilan University · ILStanford University · USHoward Hughes Medical Institute · USWeizmann Institute of Science · IL

Funding

GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Profiling and Dissecting the Dynamic Regulation of RNA EditingR01GM102484 · NIGMS · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2013 to 2021
$3.1M
Systematic characterization of trans regulation of A-to-I RNA editing in neuronsR01MH115080 · NIMH · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2017 to 2021
$2.3M
Systematic approaches to deciphering cis regulation of A-to-I RNA editingR01GM124215 · NIGMS · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2017 to 2020
$1.7M
NIGMS NIH HHS R01 GM102484NIGMS NIH HHS R01 GM124215NIGMS NIH HHS T32 GM007790NIMH NIH HHS R01 MH115080
6 · The paper itself

Abstract

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a ubiquitous mechanism that generates transcriptomic diversity. This process is particularly important for proper neuronal function; however, little is known about how RNA editing is dynamically regulated between the many functionally distinct neuronal populations of the brain. Here, we present a spatial RNA editing map in the

Indexed as

AdenosineInosineRNA EditingTranscriptomeAmino Acid SequenceAnimalsBrainDrosophilaFluorescent Antibody TechniqueMicroscopy, ConfocalModels, MolecularNeuronsProtein ConformationVoltage-Dependent Anion ChannelsAdenosineInosineVoltage-Dependent Anion ChannelsDrosophilaneuronsRNA editing

Identifiers

PMID30659150
PMCPMC6369821
OpenAlexW2884630969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.