Evidence map›Paper›PMID 30659111›Full record

ArticleJournal of cell science2019

A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia.

Tyler Picariello, Jason M Brown, Yuqing Hou, Gregory Swank, Deborah A Cochran, Oliver D King, Karl Lechtreck, Gregory J Pazour, George B Witman

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
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  8. Article
  9. The intraflagellar transport cycle.Nature reviews. Molecular cell biology · 2025
    Review
  10. Article
  11. The methylome of motile cilia.Molecular biology of the cell · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Primary cilia-associated protein IFT172 in ciliopathies.Frontiers in cell and developmental biology · 2023
    Review
  19. Appearing and disappearing acts of cilia.Journal of biosciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tyler PicarielloDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.ORCID 0000-0003-0049-1148
Jason M BrownDepartment of Biology, Salem State University, Salem, MA 01970, USA.
Yuqing HouDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Gregory SwankDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.ORCID 0000-0001-8256-5336
Deborah A CochranDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Oliver D KingDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Karl LechtreckDepartment of Cellular Biology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-6219-6470
Gregory J PazourProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
George B WitmanDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA George.Witman@umassmed.edu.ORCID 0000-0002-9497-9218
University of Massachusetts Chan Medical School · USSalem State University · USUniversity of Georgia · US

Funding

PILOT AND FEASIBILITY PROGRAMP30DK032520 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2010
$14.6M
Intraflagellar Transport Proteins in MiceR01GM060992 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gregory J Pazour · 2001 to 2026
$10.3M
Flagellar Motility and AssemlbyR37GM030626 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WITMAN, GEORGE B · 2007 to 2016
$6.3M
Flagellar Motility and AssemblyR35GM122574 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WITMAN, GEORGE B · 2017 to 2021
$3.1M
MOLECULAR MECHANISM OF FLAGELLAR MOTILITYR01GM030626 · NIGMS · WORCESTER FOUNDATION FOR BIOMEDICAL RES · PI WITMAN, GEORGE B · 1985 to 2006
$3.0M
Regulation of protein transport in ciliaR01GM110413 · NIGMS · UNIVERSITY OF GEORGIA · PI LECHTRECK, KARL · 2014 to 2022
$2.7M
Trafficking of Cystoproteins to the Primary CiliumR01DK103632 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PAZOUR, GREGORY J · 2015 to 2019
$1.9M
NIDDK NIH HHS P30 DK032520NIDDK NIH HHS R01 DK103632NIGMS NIH HHS R01 GM030626NIGMS NIH HHS R01 GM060992NIGMS NIH HHS R01 GM110413NIGMS NIH HHS R35 GM122574NIGMS NIH HHS R37 GM030626
6 · The paper itself

Abstract

Intraflagellar transport (IFT), which is essential for the formation and function of cilia in most organisms, is the trafficking of IFT trains (i.e. assemblies of IFT particles) that carry cargo within the cilium. Defects in IFT cause several human diseases. IFT trains contain the complexes IFT-A and IFT-B. To dissect the functions of these complexes, we studied a

Indexed as

Algal ProteinsAxonemeCarrier ProteinsCell MembraneCerebellar AtaxiaChlamydomonas reinhardtiiCiliaEllis-Van Creveld SyndromeFlagellaGene ExpressionGenes, ReporterGreen Fluorescent ProteinsHumansLipid-Linked ProteinsLuminescent ProteinsMonomeric GTP-Binding ProteinsAlgal ProteinsCarrier ProteinsGreen Fluorescent ProteinsIFT140 protein, humanLipid-Linked ProteinsLuminescent ProteinsMonomeric GTP-Binding ProteinsRed Fluorescent ProteinBBSomeFlagellaGTPasesIntraflagellar transportJeune asphyxiating thoracic dystrophy (JATD)Mainzer-Saldino syndrome (MSS)

Identifiers

PMID30659111
PMCPMC6382014
OpenAlexW2910064584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.