ArticleJournal of immunology (Baltimore, Md. : 1950)2019
Myeloid
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In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 122 citations in OpenAlex.
- A novel glutamine metabolism-based classification system for characterizing the heterogeneity of hepatocellular carcinoma.Journal of gastrointestinal oncology · 2026Article
- Upregulated GLUT1 expression correlates with type I interferon activity and disease severity in cutaneous lupus erythematosus.Journal of translational autoimmunity · 2026Article
- Comparative evaluation of a novel phytochemical mixture and monensin on host- and pathogen-targeted strategies in broiler chickens challenged with Eimeria maxima.Poultry science · 2026Article
- Mitochondrial metabolic reprogramming, quality control, and intercellular transfer in regulating macrophage plasticity.Frontiers in physiology · 2026Review
- Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders.Frontiers in immunology · 2026Review
- Phytochemical Monomers Derived from Traditional Chinese Medicine May Prevent and Treat Atherosclerosis by Modulating the Macrophage Mitochondrial-Lysosomal Senescence Axis.International journal of general medicine · 2026Review
- Role of Myeloid Cell Glucose Transporter 1 in the Host Response During Pneumonia Caused byInternational journal of molecular sciences · 2025Article
- Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis.Nature metabolism · 2025Article
- Unraveling the Complex Nexus of Macrophage Metabolism, Periodontitis, and Associated Comorbidities.Journal of innate immunity · 2025Review
- Incretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression.npj metabolic health and disease · 2025Article
- miR-210 promotes the anti-inflammatory phenotype and M2 polarization in murine macrophages.Frontiers in immunology · 2025Article
- The role of efferocytosis in inflammatory bowel disease.Frontiers in immunology · 2025Review
- Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease.Nature reviews. Nephrology · 2025Review
- UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling.Nature immunology · 2024Article
- Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice.Nature communications · 2024Article
- Allergens induce upregulated IL-18 and IL-18Rα expression in blood Th2 and Th17 cells of patients with allergic asthma.Clinical and experimental immunology · 2024Article
- mTOR signaling is required for phagocyte free radical production, GLUT1 expression, and control ofmBio · 2024Article
- UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling.Research square · 2024Article
- Article
- Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities.Nature metabolism · 2024Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 7 institutions in 1 country.
Alex J FreemermanDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799.
Liyang ZhaoDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799.ORCID 0000-0003-1960-0199
Ajeeth K PingiliDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.
Bin TengDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.
Alyssa J CozzoDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799.
Ashley M FullerDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Amy R JohnsonDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799.
J Justin MilnerDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799.ORCID 0000-0002-0752-2130
Maili F LimDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799.
Joseph A GalankoDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Melinda A BeckDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799.ORCID 0000-0003-4871-6828
James E BearDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Jeremy D RottyDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Lavanya BezavadaDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163.
Heather S SmallwoodDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163.
Michelle A PuchowiczDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163.
Juan LiuDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710.
Jason W LocasaleDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710.ORCID 0000-0002-7766-3502
Douglas P LeeOmic Insight, Inc., Durham, NC 27713.
Brian J BennettU.S. Department of Agriculture Western Human Nutrition Research Center, Davis, CA 95616.ORCID 0000-0002-0766-3195
E Dale AbelDivision of Endocrinology and Metabolism, University of Iowa Carver College of Medicine, Iowa City, IA 52242.ORCID 0000-0001-5290-0738
Jeff C RathmellDepartment of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, TN 37232.
Liza MakowskiDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 25799; liza.makowski@uthsc.edu.ORCID 0000-0002-5337-8037
University of North Carolina at Chapel Hill · USUniversity of Tennessee Health Science Center · USDuke University · USStrategic Insight (United States) · USUniversity of Iowa · USVanderbilt University · USWestern Human Nutrition Research Center · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MExploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory diseaseR01DK105550 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2015 to 2026
$4.7MTargeting TH17 cell metabolism in steroid resistanceR01HL136664 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWCOMB, DAWN C, RATHMELL, JEFFREY C. · 2017 to 2024
$4.2MModeling Diabetic Cardiomyopathy and Microangiopathy U01HL087947 · NHLBI · UNIVERSITY OF UTAH · PI ABEL, E DALE · 2006 to 2010
$1.8MThe role of the Arp2/3 complex in cellular actin dynamicsR01GM111557 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BEAR, JAMES E · 2014 to 2018
$1.5MSystems Genetic Studies of TMAO regulation and AtherosclerosisR01HL128572 · NHLBI · U.S. AGRICULTURAL RESEARCH SERVICE · PI BENNETT, BRIAN JOSEPH · 2015 to 2019
$1.4MMacrophage Mitochondrial Stress in Inflammation, Insulin Resistance & ObesityR00AA017376 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAKOWSKI-HAYES, LIZA · 2010 to 2012
$728kData commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598kNCI NIH HHS P30 CA016086NHLBI NIH HHS R01 HL128572NHLBI NIH HHS R01 HL136664NHLBI NIH HHS U01 HL087947NIAAA NIH HHS R00 AA017376NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK105550NIGMS NIH HHS R01 GM111557NIH HHS S10 OD018164
Abstract
Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory activation is increased flux through glycolysis with a downregulation of oxidative metabolism, whereas alternative activation is primarily oxidative, which begs the question of whether targeting glucose metabolism is a viable approach to control MΦ activation. We created a murine model of myeloid-specific glucose transporter GLUT1 (
Indexed as
Disease Models, AnimalAnimalsGlucose Transporter Type 1MacrophagesMiceMice, Inbred C57BLMice, KnockoutPhenotypeGlucose Transporter Type 1Slc2a1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.