ArticleThe Journal of biological chemistry2019
SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Downregulation of ferroptosis-related Genes can regulate the invasion and migration of osteosarcoma cells.Scientific reports · 2025Article
- Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024Review
- Gut microbiota bridges the iron homeostasis and host health.Science China. Life sciences · 2023Review
- Meta-QTLs, ortho-MetaQTLs and candidate genes for grain Fe and Zn contents in wheat (Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment.Frontiers in pharmacology · 2022Review
- Article
- Relationship between Down-Regulation of Copper-Related Genes and Decreased Ferroportin Protein Level in the Duodenum of Iron-Deficient Piglets.Nutrients · 2020Article
- SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis.Cell death & disease · 2020Article
- Time-Varying Gene Network Analysis of Human Prefrontal Cortex Development.Frontiers in genetics · 2020Article
- Creatine uptake regulates CD8 T cell antitumor immunity.The Journal of experimental medicine · 2019Article
- A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling.The Journal of biological chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Hypoxia-inducible factor 2α (HIF2α) directly regulates a battery of genes essential for intestinal iron absorption. Interestingly, iron deficiency and overload disorders do not result in increased intestinal expression of glycolytic or angiogenic HIF2α target genes. Similarly, inflammatory and tumor foci can induce a distinct subset of HIF2α target genes
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.