Evidence map›Paper›PMID 30659094›Full record

ArticleThe Journal of biological chemistry2019

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion.

Samantha D Heitz, David J Hamelin, Reece M Hoffmann, Nili Greenberg, Gilbert Salloum, Zahra Erami, Bassem D Khalil, Aliaksei Shymanets, Elizabeth A Steidle, Grace Q Gong and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Making PI3K superfamily enzymes run faster.Advances in biological regulation · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. PI3Kβ links integrin activation and PI(3,4)PMolecular biology of the cell · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 5 countries.

Samantha D HeitzFrom the Departments of Molecular Pharmacology and.
David J HamelinDepartment of Biochemistry and Microbiology, University of Victoria, Victoria V8P 3E6, British Columba, Canada.
Reece M HoffmannDepartment of Biochemistry and Microbiology, University of Victoria, Victoria V8P 3E6, British Columba, Canada.ORCID 0000-0003-4838-6849
Nili GreenbergFrom the Departments of Molecular Pharmacology and.
Gilbert SalloumFrom the Departments of Molecular Pharmacology and.
Zahra EramiFrom the Departments of Molecular Pharmacology and.
Bassem D KhalilFrom the Departments of Molecular Pharmacology and.
Aliaksei ShymanetsDepartment of Pharmacology and Experimental Therapy, Institute for Pharmacology and Toxicology and Interfaculty Center of Pharmacogenomics and Pharma Research, Eberhard-Karls-Universität Tübingen, Tübingen D-72074, Germany, and.
Elizabeth A SteidleFrom the Departments of Molecular Pharmacology and.
Grace Q GongMolecular Medicine and Pathology, Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland Private Bag 92019, New Zealand.
Bernd NürnbergDepartment of Pharmacology and Experimental Therapy, Institute for Pharmacology and Toxicology and Interfaculty Center of Pharmacogenomics and Pharma Research, Eberhard-Karls-Universität Tübingen, Tübingen D-72074, Germany, and.ORCID 0000-0002-5995-6555
John E BurkeDepartment of Biochemistry and Microbiology, University of Victoria, Victoria V8P 3E6, British Columba, Canada.ORCID 0000-0001-7904-9859
Jack U FlanaganMolecular Medicine and Pathology, Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland Private Bag 92019, New Zealand.
Anne R BresnickBiochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, anne.bresnick@einstein.yu.edu.
Jonathan M BackerFrom the Departments of Molecular Pharmacology and jonathan.backer@einstein.yu.edu.ORCID 0000-0002-0360-5692
Albert Einstein College of Medicine · USUniversity of Victoria · CAUniversity of Auckland · NZUniversity of Tübingen · DE

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
Tumor Progression and MetastasisP01CA100324 · NCI · YESHIVA UNIVERSITY · PI CONDEELIS, JOHN S · 2003 to 2018
$30.0M
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA programK12GM102779 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Dianne Cox, Johanna Patricia Daily · 2012 to 2026
$9.2M
Training in Aging ResearchT32AG023475 · NIA · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI NIR J BARZILAI, DEREK Major HUFFMAN · 2004 to 2026
$8.6M
The Role of PI3K Beta in Breast Cancer MetastasisR01GM119279 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BACKER, JONATHAN M., BRESNICK, ANNE R · 2016 to 2019
$1.5M
NCI NIH HHS P01 CA100324NCI NIH HHS P30 CA013330NIA NIH HHS T32 AG023475NIGMS NIH HHS K12 GM102779NIGMS NIH HHS R01 GM119279NIGMS NIH HHS T32 GM007491
6 · The paper itself

Abstract

Phosphoinositide 3-kinase β (PI3Kβ) is regulated by receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), and small GTPases such as Rac1 and Rab5. Our lab previously identified two residues (Gln

Indexed as

Neoplasm InvasivenessBinding SitesBreast NeoplasmsCell Line, TumorChemotaxisGelatinHEK293 CellsHumansMass SpectrometryMutationPhosphatidylinositol 3-KinaseProtein Bindingrab5 GTP-Binding ProteinsGelatinPhosphatidylinositol 3-KinaseRAB5C protein, humanrab5 GTP-Binding Proteinsbreast cancerchemotaxisG protein-coupled receptor (GPCR)GTPaseinvasionmatrix degradationp85phosphoinositide 3-kinase (PI 3-kinase)PIK3CBPIK3R1Rabreceptor tyrosine kinase

Identifiers

PMID30659094
PMCPMC6433078
OpenAlexW2910350903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.