ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
The Ventral Midline Thalamus Mediates Hippocampal Spatial Information Processes upon Spatial Cue Changes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep.Science (New York, N.Y.) · 2025Article
- The reuniens thalamus recruits recurrent excitation in the medial prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Distinct Disruptions in CA1 and CA3 Place Cell Function in Alzheimer's Disease Mice.bioRxiv : the preprint server for biology · 2024Article
- Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs).Human brain mapping · 2024Article
- A Comprehensive Overview of the Neural Mechanisms of Light Therapy.Neuroscience bulletin · 2024Review
- The medial entorhinal cortex is necessary for the stimulus control over hippocampal place fields by distal, but not proximal, landmarks.Hippocampus · 2023Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Chemogenetic inactivation of the nucleus reuniens impairs object placement memory in female mice.Neurobiology of learning and memory · 2021Article
- The Thalamus as a Blackboard for Perception and Planning.Frontiers in behavioral neuroscience · 2021Article
- Novel Heat-Mitigating Chip-on-Probe for Brain Stimulation Behavior Experiments.Sensors (Basel, Switzerland) · 2020Article
- Involvement of the Postrhinal and Perirhinal Cortices in Microscale and Macroscale Visuospatial Information Encoding.Frontiers in behavioral neuroscience · 2020Article
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3 authors.
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Abstract
The ventral midline thalamus, consisting of the reuniens and rhomboid nuclei (RE/Rh), is a thalamic structure interconnected with the limbic systems including the hippocampus. Recently, many studies have revealed that this structure plays distinctive roles in spatial learning and memory in collaboration with hippocampal functions. However, what aspects of spatial information process are influenced by the RE/Rh is not clearly known. To elucidate the roles of RE/Rh in spatial information processing and its effects on hippocampal activity, specifically with the manipulation of spatial contents, we measured hippocampal-dependent spatial memory performance and hippocampal place cell activities after RE/Rh lesion using male C57BL/6J × 129/SvJae hybrid mice. We found that the lesion altered the behavioral aptitude in recognizing locational changes of an object. Furthermore, CA1 place cells in the lesion group showed different spatial representation patterns in recognizing the environment with cue locational changes compared with the control group. Interestingly, the patterns of CA1 place cells in recognizing the same environment previously visited were not disrupted in the lesion group compared with the control group. These findings demonstrate that the ventral midline thalamus (RE/Rh) is important in recognizing the spatial relationships, especially when spatial rearrangement of cue position was introduced.
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