Evidence map›Paper›PMID 30659065›Full record

ArticleMolecular & cellular proteomics : MCP2019

Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific

Kevin Brown Chandler, Nickita Mehta, Deborah R Leon, Todd J Suscovich, Galit Alter, Catherine E Costello

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Article
  3. Glycan Structures of Human Immunoglobulins and Their Roles.Advances in experimental medicine and biology · 2026
    Review
  4. N-Glycan-Dependent Proinflammatory Effects of IgM in Anti-MAG Neuropathy.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Article
  5. Raider of the lostFrontiers in molecular biosciences · 2025
    Article
  6. Article
  7. Immunoglobulin A carries sulfated andFrontiers in molecular biosciences · 2025
    Article
  8. Article
  9. Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
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  18. Review
  19. Article
  20. Bacterial lectin BambL acts as a B cell superantigen.Cellular and molecular life sciences : CMLS · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kevin Brown ChandlerFrom the ‡Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts.
Nickita MehtaRagon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.
Deborah R LeonFrom the ‡Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts.
Todd J SuscovichRagon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.
Galit AlterRagon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.
Catherine E CostelloFrom the ‡Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts;. Electronic address: cecmsms@bu.edu.
Boston University · USRagon Institute of MGH, MIT and Harvard · US

Funding

Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4M
Demystifying the antiviral activity of the IgG3+ antibody responseR37AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTER, GALIT · 2015 to 2022
$5.8M
Legacy Support During Closure of the Mass Spectrometry Resource for Biology and MedicineR24GM134210 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2019 to 2021
$2.1M
MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCHS10OD010724 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2012
$590k
A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry SystemS10OD021651 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2016 to 2016
$580k
Impaired Glycosylation of Vascular Endothelial Growth Factor Receptor 2 in Tumor AngiogenesisF32CA196157 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDLER, KEVIN BROWN · 2015 to 2017
$168k
NCI NIH HHS F32 CA196157NIAID NIH HHS R37 AI080289NIGMS NIH HHS P41 GM104603NIGMS NIH HHS R24 GM134210NIH HHS S10 OD010724NIH HHS S10 OD021651
6 · The paper itself

Abstract

Antibodies are critical glycoproteins that bridge the innate and adaptive immune systems to provide protection against infection. The isotype/subclass of the antibody, the co-translational

Indexed as

ProteomicsAmino Acid SequenceGlycoproteinsGlycosylationHumansImmunoglobulin Heavy ChainsImmunoglobulin IsotypesGlycoproteinsImmunoglobulin Heavy ChainsImmunoglobulin IsotypesAntibodies*GlycoproteomicsImmunoglobulin G1 (IgG1)Immunoglobulin G4 (IgG4)Immunoglobulin M (IgM)Immunoglobulins A1 and A2 (IgA1 and IgA2)Immunology*N-Glycosylationsequence variantSerum/Plasma*

Identifiers

PMID30659065
PMCPMC6442369
OpenAlexW2909425791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.