Evidence map›Paper›PMID 30659035›Full record

ArticleBMJ open2019

Protocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients.

Daniel S Martin, Chris Brew-Graves, Neil McCartan, Gavin Jell, Ingrid Potyka, Jia Stevens, Norman R Williams, Margaret McNeil, B Ronan O'Driscoll, Monty Mythen and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03287466 (A Randomised Controlled Trial of Targeted Oxygen Therapy in Mechanically Ventilated Critically Ill Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03287466 nacompletednot on this map

A Randomised Controlled Trial of Targeted Oxygen Therapy in Mechanically Ventilated Critically Ill Patients

TypeinterventionalSponsorUniversity College, LondonRan2018 to 2020Enrolled34ConditionsCritical Illness, Respiratory FailureArmsOxygen
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Daniel S MartinCritical Care Unit, Royal Free Hospital, London, UK.ORCID 0000-0001-6220-8235
Chris Brew-GravesSurgical and Interventional Trials Unit, Division of Surgery and Interventional Science, University College London, London, UK.
Neil McCartanSurgical and Interventional Trials Unit, Division of Surgery and Interventional Science, University College London, London, UK.
Gavin JellDivision of Surgery and Interventional Science, Royal Free Hospital, University College London, London, UK.
Ingrid PotykaSurgical and Interventional Trials Unit, Division of Surgery and Interventional Science, University College London, London, UK.
Jia StevensCritical Care Unit, Royal Free Hospital, London, UK.
Norman R WilliamsSurgical and Interventional Trials Unit, Division of Surgery and Interventional Science, University College London, London, UK.
Margaret McNeilCritical Care Unit, Royal Free Hospital, London, UK.
B Ronan O'DriscollManchester Academic Health Sciences Centre, Salford Royal Foundation NHS Trust, Salford, UK.
Monty MythenAnaesthesia and Critical Care, University College London Hospitals National Institute of Health Research Biomedical Research Centre, London, UK.
Michael P W GrocottIntegrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
The Royal Free Hospital · GBUniversity College London · GBNational Institute for Health Research · GBSalford Royal NHS Foundation Trust · GBUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Department of Health PB-PG-0815-20006
6 · The paper itself

Abstract

introductionOxygen is the most commonly administered drug to mechanically ventilated critically ill adults, yet little is known about the optimum oxygen saturation (SpO METHODS AND ANALYSIS: Targeted OXygen therapY in Critical illness (TOXYC) is a feasibility randomised controlled trial (RCT) to evaluate whether recruiting patients to a study of permissive hypoxaemia is possible in the UK. It will also investigate biological mechanisms that may underlie the links between oxygenation and patient outcomes. Mechanically ventilated patients with respiratory failure will be recruited from critical care units at two sites and randomised (1:1 ratio) to an SpO ETHICS AND DISSEMINATION: This study was approved by the London - Harrow Research Ethics Committee on 2 November 2017 (REC Reference 17/LO/1334) and received HRA approval on 13 November 2017. Results from this study will be disseminated in peer-reviewed journals, at medical and scientific meetings, in the NIHR Journals Library and patient information websites. TRIAL REGISTRATION NUMBER: NCT03287466; Pre-results.

Indexed as

Oxidative StressRespiration, ArtificialBiomarkersCritical CareCritical IllnessFeasibility StudiesHumansHypoxiaMulticenter Studies as TopicOxygenOxygen Inhalation TherapyRandomized Controlled Trials as TopicReactive Oxygen SpeciesRespiratory InsufficiencyUnited KingdomBiomarkersOxygenReactive Oxygen Speciesartificial respirationhypoxiaoxidative stressoxygenrespiratory insufficiency

Identifiers

PMID30659035
PMCPMC6340470
OpenAlexW2910205035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.