ReviewParkinsonism & related disorders2019
A review of basal ganglia circuits and physiology: Application to deep brain stimulation.
Review in Parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Basal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review.Journal of Parkinson's disease · 2026Pooled it
- Interference of functional dual-tasks on gait in untrained people with Parkinson's disease and healthy controls: a cross-sectional study.BMC musculoskeletal disorders · 2020Trial
- Striatal pathways oppositely shift cortical activity along the decision axis.bioRxiv : the preprint server for biology · 2025Article
- Histamine Modulation of the Basal Ganglia Circuitry in the Motor Symptoms of Parkinson's Disease.CNS neuroscience & therapeutics · 2025Review
- Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson's disease.Frontiers in neuroscience · 2025Article
- Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses.bioRxiv : the preprint server for biology · 2024Article
- BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson's Disease and Dystonia.Biomedicines · 2024Review
- Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson's disease.Nature communications · 2024Article
- Radiofrequency Ablation: How to Ensure Worldwide Availability of Surgery for Parkinson's Disease.Movement disorders clinical practice · 2024Article
- Electrocardiographic approach strategies in patients with Parkinson disease treated with deep brain stimulation.Frontiers in cardiovascular medicine · 2024Review
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- Article
- Substantia Nigra Pars Reticulata Projections to the Pedunculopontine Nucleus Modulate Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Weight and survival after deep brain stimulation for Parkinson's disease.Parkinsonism & related disorders · 2023Article
- Subthalamic Nucleus Activity during Cognitive Load and Gait Dysfunction in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Neural oscillatory characteristics of feedback-associated activity in globus pallidus interna.Scientific reports · 2023Article
- Closed-Loop Adaptive Deep Brain Stimulation in Parkinson's Disease: Procedures to Achieve It and Future Perspectives.Journal of Parkinson's disease · 2023Review
- Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation.Frontiers in human neuroscience · 2023Article
- Effectiveness of Thalamic Ventralis Oralis Anterior and Posterior Nuclei Deep Brain Stimulation for Posttraumatic Dystonia.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionDrawing on the seminal work of DeLong, Albin, and Young, we have now entered an era of basal ganglia neuromodulation. Understanding, re-evaluating, and leveraging the lessons learned from neuromodulation will be crucial to facilitate an increased and improved application of neuromodulation in human disease.
methodsWe will focus on deep brain stimulation (DBS) - the most common form of basal ganglia neuromodulation - however, similar principles can apply to other neuromodulation modalities. We start with a brief review of DBS for Parkinson's disease, essential tremor, dystonia, and Tourette syndrome. We then review hallmark studies on basal ganglia circuits and electrophysiology resulting from decades of experience in neuromodulation. The organization and content of this paper follow Dr. Okun's Lecture from the 2018 Parkinsonism and Related Disorders World Congress.
resultsInformation gained from neuromodulation has led to an expansion of the basal ganglia rate model, an enhanced understanding of nuclei dynamics, an emerging focus on pathological oscillations, a revision of the tripartite division of the basal ganglia, and a redirected focus toward individualized symptom-specific stimulation. Though there have been many limitations of the basal ganglia "box model," the construct provided the necessary foundation to advance the field. We now understand that information in the basal ganglia is encoded through complex neural responses that can be reliably measured and used to infer disease states for clinical translation.
conclusionsOur deepened understanding of basal ganglia physiology will drive new neuromodulation strategies such as adaptive DBS or cell-specific neuromodulation through the use of optogenetics.
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