ArticleNeuron2019
Functional Synaptic Architecture of Callosal Inputs in Mouse Primary Visual Cortex.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons.iScience · 2026Article
- Behavioural states control binocular vision through input-specific mechanisms.Nature communications · 2026Article
- Emergence of a brainstem somatosensory tonotopic map for substrate vibration.Nature neuroscience · 2025Article
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Expanding boundaries - a cell biologist's guide to expansion microscopy.Journal of cell science · 2024Review
- A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing.Nature communications · 2023Article
- Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Applying the Properties of Neurons in Machine Learning: A Brain-like Neural Model with Interactive Stimulation for Data Classification.Brain sciences · 2022Article
- Emergence of synaptic organization and computation in dendrites.Neuroforum · 2022Review
- Two-photon calcium imaging of neuronal activity.Nature reviews. Methods primers · 2022Article
- The functional characterization of callosal connections.Progress in neurobiology · 2022Review
- Diverse processing underlying frequency integration in midbrain neurons of barn owls.PLoS computational biology · 2021Article
- Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.Neuron · 2021Article
- Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.International journal of molecular sciences · 2021Article
- How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model.Annual review of neuroscience · 2021Review
- Expansion microscopy: A powerful nanoscale imaging tool for neuroscientists.Neurobiology of disease · 2021Review
- Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex.Neuron · 2021Article
- Portrait of visual cortical circuits for generating neural oscillation dynamics.Cognitive neurodynamics · 2021Review
- Spatial clustering of orientation preference in primary visual cortex of the large rodent agouti.iScience · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Callosal projections are thought to play a critical role in coordinating neural activity between the cerebral hemispheres in placental mammals, but the rules that govern the arrangement of callosal synapses on the dendrites of their target neurons remain poorly understood. Here we describe a high-throughput method to map the functional organization of callosal connectivity by combining in vivo 3D random-access two-photon calcium imaging of the dendritic spines of single V1 neurons with optogenetic stimulation of the presynaptic neural population in the contralateral hemisphere. We find that callosal-recipient spines are more likely to cluster with non-callosal-recipient spines with similar orientation preference. These observations, based on optogenetic stimulation, were confirmed by direct anatomical visualization of callosal synaptic connections using post hoc expansion microscopy. Our results demonstrate, for the first time, that functional synaptic clustering in a short dendritic segment could play a role in integrating distinct neuronal circuits.
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Registered trials
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