Evidence map›Paper›PMID 30658615›Full record

ArticleBMC pulmonary medicine2019

Development and validation of a simple-to-use clinical nomogram for predicting obstructive sleep apnea.

Huajun Xu, Xiaolong Zhao, Yue Shi, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Hengye Huang, Jian Guan, Shankai Yin

Open access · goldAbstract readValidation Study
In one paragraph

Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Huajun XuDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China.
Xiaolong ZhaoDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China.
Yue ShiDepartment of Epidemiology, School of Public Health, Shanghai Jiao Tong University, 225South Chongqing Road, Shanghai, 200020, China.
Xinyi LiDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China.
Yingjun QianDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China.
Jianyin ZouDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China.
Hongliang YiDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China. yihongl@126.com.
Hengye HuangDepartment of Epidemiology, School of Public Health, Shanghai Jiao Tong University, 225South Chongqing Road, Shanghai, 200020, China. huanghy1107@shsmu.edu.cn.
Jian GuanDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China. guanjian0606@sina.com.
Shankai YinDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China.
Shanghai Jiao Tong University · CNShanghai Sixth People's Hospital · CN

Funding

Innovation Program of Shanghai Municipal Education Commission 2017-01-07-00-02-E00047multi-center clinical research project from school of medicine, Shanghai Jiao Tong University DLY201502National Key R&D Program of China 2017YFC0112500National Natural Science Foundation of China 81700896National Natural Science Foundation of China 81770987Shanghai Sailing Program 17YF1414300Shanghai Shen-Kang Hospital Management Center Project SHDC12015101
6 · The paper itself

Abstract

backgroundThe high cost and low availability of polysomnography (PSG) limits the timely diagnosis of OSA. Herein, we developed and validated a simple-to-use nomogram for predicting OSA.

methodsWe collected and analyzed the cross-sectional data of 4162 participants with suspected OSA, seen at our sleep center between 2007 and 2016. Demographic, biochemical and anthropometric data, as well as sleep parameters were obtained. A least absolute shrinkage and selection operator (LASSO) regression model was used to reduce data dimensionality, select factors, and construct the nomogram. The performance of the nomogram was assessed using calibration and discrimination. Internal validation was also performed.

resultsThe LASSO regression analysis identified age, sex, body mass index, neck circumference, waist circumference, glucose, insulin, and apolipoprotein B as significant predictive factors of OSA. Our nomogram model showed good discrimination and calibration in terms of predicting OSA, and had a C-index value of 0.839 according to the internal validation. Discrimination and calibration in the validation group was also good (C-index = 0.820). The nomogram identified individuals at risk for OSA with an area under the curve (AUC) of 0.84 [95% confidence interval (CI), 0.83-0.86].

conclusionsOur simple-to-use nomogram is not intended to replace standard PSG, but will help physicians better make decisions on PSG arrangement for the patients referred to sleep center.

Indexed as

NomogramsAdultAge FactorsAnthropometryApolipoproteins BArea Under CurveBlood GlucoseBody Mass IndexCross-Sectional StudiesFemaleHumansInsulinMaleMiddle AgedNeckPolysomnographyApolipoproteins BBlood GlucoseInsulinNomogramObstructive sleep apneaRisk factor

Identifiers

PMID30658615
PMCPMC6339352
OpenAlexW2911730075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.