Evidence map›Paper›PMID 30658483›Full record

Trial reportNutrients2019

A Randomized, Controlled Trial of Vitamin D Supplementation on Cardiovascular Risk Factors, Hormones, and Liver Markers in Women with Polycystic Ovary Syndrome.

Zeeshan Javed, Maria Papageorgiou, Harshal Deshmukh, Eric S Kilpatrick, Vincent Mann, Lynsey Corless, George Abouda, Alan S Rigby, Stephen L Atkin, Thozhukat Sathyapalan

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02513381 (The Effect of Colecalciferol), which is not on this map. Cited by 53 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 7 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02513381 nacompletednot on this map

The Effect of Colecalciferol (Vitamin D) on Hormonal, Metabolic and Cardiovascular Risk Factors in Patients With Polycystic Ovary Syndrome (PCOS) - a Double Blind Randomised Placebo-controlled Study

TypeinterventionalSponsorHull University Teaching Hospitals NHS TrustRan2015 to 2016Enrolled40ConditionsPolycystic Ovary SyndromeArmsVitamin D3, 3200IU, Placebo
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 7 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Effects of Vitamin DNutrients · 2022
    Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Zeeshan JavedDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK. Zeeshan.Javed@pkli.org.pk.ORCID 0000-0002-8974-2371
Maria PapageorgiouDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK. m.papageorgiou@hull.ac.uk.ORCID 0000-0002-9943-6976
Harshal DeshmukhDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK. harshaldeshmukh@nhs.net.
Eric S KilpatrickDepartment of Pathology, Sidra Medical and Research Centre, Doha PO Box 26999, Qatar. ekilpatrick@sidra.org.
Vincent MannGastroenterology Research Department, Hull Royal Infirmary, Hull HU3 2JZ, UK. Vincent.mann@hey.nhs.uk.
Lynsey CorlessGastroenterology Research Department, Hull Royal Infirmary, Hull HU3 2JZ, UK. l.corless@hull.ac.uk.
George AboudaGastroenterology Research Department, Hull Royal Infirmary, Hull HU3 2JZ, UK. George.Abouda@hey.nhs.uk.
Alan S RigbyHull York Medical School, University of Hull, Hull HU3 2JZ, UK. A.rigby@hull.ac.uk.
Stephen L AtkinWeill Cornell Medical College Qatar, Education City, Doha PO Box 24144, Qatar. sla2002@qatar-med.cornell.edu.ORCID 0000-0002-5887-7257
Thozhukat SathyapalanDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK. Thozhukat.Sathyapalan@hyms.ac.uk.ORCID 0000-0003-3544-2231
University of Hull · GBHull Royal Infirmary · GBSidra Medical and Research Center · QAWeill Cornell Medical College in Qatar · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemistry in patients with NAFLD; however, its effects on PCOS are unknown. This randomized, double-blind, placebo-controlled study explored the effect of vitamin D supplementation on cardiovascular risk factors (high-sensitivity C-reactive protein (

Indexed as

Dietary SupplementsAdolescentAdultAlanine TransaminaseBiomarkersBlood GlucoseBody Mass IndexCardiovascular DiseasesCholesterolC-Reactive ProteinDouble-Blind MethodFemaleHumansHyaluronic AcidInsulinInsulin ResistanceAlanine TransaminaseBiomarkersBlood GlucoseCholesterolC-Reactive ProteinHyaluronic AcidInsulinSex Hormone-Binding GlobulinTestosteroneTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1TriglyceridesVitamin Dcardiovascular risk factorshormonesliver markerspolycystic ovary syndromevitamin D

Identifiers

PMID30658483
PMCPMC6356309
OpenAlexW2910609097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.