Evidence map›Paper›PMID 30658445›Full record

ArticleViruses2019

Co-Delivery Effect of CD24 on the Immunogenicity and Lethal Challenge Protection of a DNA Vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus.

Touraj Aligholipour Farzani, Alireza Hanifehnezhad, Katalin Földes, Koray Ergünay, Erkan Yilmaz, Hiba Hashim Mohamed Ali, Aykut Ozkul

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Touraj Aligholipour FarzaniVirology Department, Faculty of Veterinary Medicine, Ankara University, Ankara 06110, Turkey. touraj.farzani@gmail.com.ORCID 0000-0002-1392-4048
Alireza HanifehnezhadVirology Department, Faculty of Veterinary Medicine, Ankara University, Ankara 06110, Turkey. alireza.hanifehnezhad@gmail.com.
Katalin FöldesVirology Department, Faculty of Veterinary Medicine, Ankara University, Ankara 06110, Turkey. fldeskatalin@gmail.com.
Koray ErgünayVirology Unit, Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey. ekoray@hacettepe.edu.tr.
Erkan YilmazBiotechnology Institute, Ankara University, Ankara 06560, Turkey. eyilmaz@ankara.edu.tr.
Hiba Hashim Mohamed AliVirology Department, Faculty of Veterinary Medicine, Ankara University, Ankara 06110, Turkey. hibaziada@yahoo.com.
Aykut OzkulVirology Department, Faculty of Veterinary Medicine, Ankara University, Ankara 06110, Turkey. ozkul@ankara.edu.tr.ORCID 0000-0001-5008-9443
Ankara University · TRHacettepe University · TR

Funding

Ankara Universitesi SBAG 115 S 074
6 · The paper itself

Abstract

Crimean Congo hemorrhagic fever virus (CCHFV) is the causative agent of a globally-spread tick-borne zoonotic infection, with an eminent risk of fatal human disease. The imminent public health threat posed by the disseminated virus activity and lack of an approved therapeutic make CCHFV an urgent target for vaccine development. We described the construction of a DNA vector expressing a nucleocapsid protein (N) of CCHFV (pV-N13), and investigated its potential to stimulate the cytokine and total/specific antibody responses in BALB/c and a challenge experiment in IFNAR

Indexed as

Immunogenicity, VaccineAnimalsAntibodies, NeutralizingAntibodies, ViralCD24 AntigenCytokinesDisease Models, AnimalFemaleGenetic VectorsHemorrhagic Fever, CrimeanHemorrhagic Fever Virus, Crimean-CongoMice, Inbred BALB CMice, KnockoutNucleocapsid ProteinsReceptor, Interferon alpha-betaVaccines, DNAAntibodies, NeutralizingAntibodies, ViralCD24 AntigenCytokinesNucleocapsid ProteinsReceptor, Interferon alpha-betaVaccines, DNACCHFVCD24CytokinesIFNAR−/− miceLethal Challengenucleocapsid

Identifiers

PMID30658445
PMCPMC6356336
OpenAlexW2908554773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.