Evidence map›Paper›PMID 30658436›Full record

ArticleCancers2019

FOSB⁻PCDHB13 Axis Disrupts the Microtubule Network in Non-Small Cell Lung Cancer.

Chen-Hung Ting, Kang-Yun Lee, Sheng-Ming Wu, Po-Hao Feng, Yao-Fei Chan, Yi-Chun Chen, Jyh-Yih Chen

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  16. Selective antagonism of cJun for cancer therapy.Journal of experimental & clinical cancer research : CR · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chen-Hung TingMarine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Ilan 262, Taiwan. koichiting@gmail.com.
Kang-Yun LeeGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. kangyunlee68@gmail.com.
Sheng-Ming WuDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan. chitosan@tmu.edu.tw.
Po-Hao FengDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan. pohao.feng@gmail.com.
Yao-Fei ChanDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan. k2201025@ms19.hinet.net.
Yi-Chun ChenMarine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Ilan 262, Taiwan. yotaka1225@gmail.com.
Jyh-Yih ChenMarine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Ilan 262, Taiwan. zoocjy@gate.sinica.edu.tw.
Institute of Cellular and Organismic Biology, Academia Sinica · TWTaipei Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWNational Chung Hsing University · TW

Funding

Ministry of Science and Technology, Taiwan MOST-105-2622-B-001-002The Ministry of Education, Taiwan MOE-107-S-0023-A
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is among the leading causes of human mortality. One reason for high rates of NSCLC mortality is that drug resistance is a major problem for both conventional chemotherapies and less-toxic targeted therapies. Thus, novel mechanistic insights into disease pathogenesis may benefit the development of urgently needed therapies. Here we show that FBJ murine osteosarcoma viral oncogene homolog B (FOSB) was induced by an antimicrobial peptide, tilapia piscidin-4 (TP4), through the dysregulation of mitochondrial Ca

Indexed as

antimicrobial peptidecytoskeletonFOSBmitochondrial stressnon-small cell lung cancer (NSCLC)protocadherin

Identifiers

PMID30658436
PMCPMC6357195
OpenAlexW2911009990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.